Details

Autor(en) / Beteiligte

• Kuczma, Michal P
• Szurek, Edyta A
• Cebula, Anna
• Chassaing, Benoit
• Jung, Yu-Jin
• Kang, Sang-Moo
• Fox, James G
• Stecher, Bärbel
• Ignatowicz, Leszek

Titel

Commensal epitopes drive differentiation of colonic Tregs

Ist Teil von

• Science advances, 2020-04, Vol.6 (16), p.eaaz3186-eaaz3186

Ort / Verlag

American Association for the Advancement of Science

Erscheinungsjahr

2020

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Colonic commensal-derived antigens support expansion and differentiation of immunosupressive CD4 T cells. The gut microbiome is the largest source of intrinsic non–self-antigens that are continuously sensed by the immune system but typically do not elicit lymphocyte responses. CD4 + T cells are critical to sustain uninterrupted tolerance to microbial antigens and to prevent intestinal inflammation. However, clinical interventions targeting commensal bacteria–specific CD4 + T cells are rare, because only a very limited number of commensal-derived epitopes have been identified. Here, we used a new approach to study epitopes and identify T cell receptors expressed by CD4 + Foxp3 + (T reg ) cells specific for commensal-derived antigens. Using this approach, we found that antigens from Akkermansia muciniphila reprogram naïve CD4 + T cells to the T reg lineage, expand preexisting microbe specific T regs , and limit wasting disease in the CD4 + T cell transfer model of colitis. These data suggest that the administration of specific commensal epitopes may help to widen the repertoire of specific T regs that control intestinal inflammation.