Details

Autor(en) / Beteiligte

• Urwyler, P.
• Earnshaw, I.
• Bermudez, M.
• Perucha, E.
• Wu, W.
• Ryan, S.
• Mcdonald, L.
• Karagiannis, S. N.
• Taams, L. S.
• Powell, N.
• Cope, A.
• Papa, S.

Titel

Mechanisms of checkpoint inhibition‐induced adverse events

Ist Teil von

• Clinical and experimental immunology, 2020-05, Vol.200 (2), p.141-154

Ort / Verlag

England: Oxford University Press

Erscheinungsjahr

2020

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Summary Immune checkpoint inhibition has revolutionized the treatment of several solid cancers, most notably melanoma and non‐small‐cell lung cancer (NSCLC). Drugs targeting cytotoxic T lymphocyte antigen (CTLA)‐4 and programmed cell death 1 (PD‐1) have made their way into routine clinical use; however, this has not been without difficulties. Stimulation of the immune system to target cancer has been found to result in a reduction of self‐tolerance, leading to the development of adverse effects that resemble autoimmunity. These adverse effects are erratic in their onset and severity and can theoretically affect any organ type. Several mechanisms for immune‐related toxicity have been investigated over recent years; however, no consensus on the cause or prediction of toxicity has been reached. This review seeks to examine reported evidence for possible mechanisms of toxicity, methods for prediction of those at risk and a discussion of future prospects within the field. Cancer Immunotherapy with checkpoint inhibitors are changing the face of systemic cancer therapy for a wide range of malignancies. These treatments come with complex immune related side effects the mechanisms of which remain incompletely understood. This review covers current evidence for toxicity mechanisms.