Nature (London), 2019-08, Vol.572 (7770), p.481-487
2019
Details
- Autor(en) / Beteiligte
- Titel
- Opposing T cell responses in experimental autoimmune encephalomyelitis
- Ist Teil von
- Nature (London), 2019-08, Vol.572 (7770), p.481-487
- Ort / Verlag
- England: Nature Publishing Group
- Erscheinungsjahr
- 2019
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Experimental autoimmune encephalomyelitis is a model for multiple sclerosis. Here we show that induction generates successive waves of clonally expanded CD4 , CD8 and γδ T cells in the blood and central nervous system, similar to gluten-challenge studies of patients with coeliac disease. We also find major expansions of CD8 T cells in patients with multiple sclerosis. In autoimmune encephalomyelitis, we find that most expanded CD4 T cells are specific for the inducing myelin peptide MOG . By contrast, surrogate peptides derived from a yeast peptide major histocompatibility complex library of some of the clonally expanded CD8 T cells inhibit disease by suppressing the proliferation of MOG-specific CD4 T cells. These results suggest that the induction of autoreactive CD4 T cells triggers an opposing mobilization of regulatory CD8 T cells.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0028-0836eISSN: 1476-4687DOI: 10.1038/s41586-019-1467-xTitel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7145319
- Format
- –
- Schlagworte
- Adult, Analysis, Animals, Antigens, Autoimmune diseases, CD4 antigen, CD4-Positive T-Lymphocytes - immunology, CD4-Positive T-Lymphocytes - pathology, CD8 antigen, CD8-Positive T-Lymphocytes - cytology, CD8-Positive T-Lymphocytes - immunology, CD8-Positive T-Lymphocytes - pathology, Celiac Disease, Cell proliferation, Central nervous system, Clone Cells - cytology, Clone Cells - immunology, Diagnosis, Disease, Encephalomyelitis, Encephalomyelitis, Autoimmune, Experimental - immunology, Encephalomyelitis, Autoimmune, Experimental - pathology, Experimental allergic encephalomyelitis, Female, Genetic aspects, Genomes, Gluten, H-2 Antigens - immunology, Humans, Immunization, Kinases, Lymphocyte Activation, Lymphocytes, Lymphocytes T, Major histocompatibility complex, Male, Mice, Mice, Inbred C57BL, Middle Aged, Multiple sclerosis, Myelin, Myelin-Associated Glycoprotein - immunology, Nervous system, Oligodendrocyte-myelin glycoprotein, Peptides, Receptors, Antigen, T-Cell - immunology, T cell receptors, T cells, T-Lymphocytes - cytology, T-Lymphocytes - immunology, T-Lymphocytes - pathology, T-Lymphocytes, Regulatory - cytology, T-Lymphocytes, Regulatory - immunology, Yeast, Yeasts, Young Adult