Details

Autor(en) / Beteiligte

• He, Ying
• Zhang, Yanbin
• Wojtas, Lukasz
• Akhmedov, Novruz G.
• Pan, Qinhe
• Guo, Hao
• Shi, Xiaodong

Titel

Reversed Cation Selectivity of G8‐Octamer and G16‐Hexadecamer towards Monovalent and Divalent Cations

Ist Teil von

• Chemistry, an Asian journal, 2020-04, Vol.15 (7), p.1030-1034

Ort / Verlag

Weinheim: Wiley Subscription Services, Inc

Erscheinungsjahr

2020

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• A reverse‐binding‐selectivity between monovalent and divalent cations was observed for two different self‐assembly G16‐hexadecamer and G8‐octamer systems. The dissociation constant between G4‐quadruplex and monomer was calculated via VT‐1H NMR experiments. Quantitative energy profiles revealed entropy as the key factor for the weaker binding toward Ba2+ compared with K+ in the G8‐octamer system despite stronger ion‐dipole interactions. This study is the first direct comparison of the G4‐quartet binding affinity between mono and divalent cations and will benefit future applications of G‐quadruplex‐related research. Further competition experiments between the G8‐octamer and 18‐crown‐6 with K+ demonstrated the potential of this G8 system as a new potassium receptor. G8‐octamer and G16‐hexadecamer showed reversed cation selectivity! Excellent K+ selectivity was achieved with a G8‐octamer system. Energetic binding profiles were determined to account for this phenomenon. This exceptional binding ability toward K+ was further demonstrated through competition experiments with crown ether 18C6.