Nature reviews. Microbiology, 2019-03, Vol.17 (3), p.181-192
2019
Details
- Autor(en) / Beteiligte
- Titel
- Origin and evolution of pathogenic coronaviruses
- Ist Teil von
- Nature reviews. Microbiology, 2019-03, Vol.17 (3), p.181-192
- Ort / Verlag
- England: Nature Publishing Group
- Erscheinungsjahr
- 2019
- Link zum Volltext
- Beschreibungen/Notizen
- Severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) are two highly transmissible and pathogenic viruses that emerged in humans at the beginning of the 21st century. Both viruses likely originated in bats, and genetically diverse coronaviruses that are related to SARS-CoV and MERS-CoV were discovered in bats worldwide. In this Review, we summarize the current knowledge on the origin and evolution of these two pathogenic coronaviruses and discuss their receptor usage; we also highlight the diversity and potential of spillover of bat-borne coronaviruses, as evidenced by the recent spillover of swine acute diarrhoea syndrome coronavirus (SADS-CoV) to pigs.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1740-1526eISSN: 1740-1534DOI: 10.1038/s41579-018-0118-9Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7097006
- Format
- –
- Schlagworte
- Alphacoronavirus - genetics, Alphacoronavirus - pathogenicity, Analysis, Animals, Bats, Bats (Animals), Biodiversity, Chiroptera, Chiroptera - virology, Coronaviridae, Coronavirus - genetics, Coronavirus - pathogenicity, Coronavirus Infections, Coronaviruses, Diarrhea, Evolution, Evolution, Molecular, Genetic aspects, Genetic Variation, Genome, Viral, Humans, Livestock, Middle East Respiratory Syndrome Coronavirus - genetics, Middle East Respiratory Syndrome Coronavirus - pathogenicity, Natural history, Origin, Phylogeny, Physiological aspects, Respiratory diseases, Review, SARS Virus - genetics, SARS Virus - pathogenicity, Severe Acute Respiratory Syndrome, Swine, Swine - virology, Viruses