Seminars in cell & developmental biology, 2017-05, Vol.65, p.11-19
2017
Details
- Autor(en) / Beteiligte
- Titel
- Mammalian microRNAs and long noncoding RNAs in the host-bacterial pathogen crosstalk
- Ist Teil von
- Seminars in cell & developmental biology, 2017-05, Vol.65, p.11-19
- Ort / Verlag
- England: Elsevier Ltd
- Erscheinungsjahr
- 2017
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Gene expression regulation is a critical question in host-pathogen interactions, and RNAs act as key players in this process. In this review, we focus on the mammalian RNA response to bacterial infection, with a special interest on microRNAs and long non-coding RNAs. We discuss the role of cellular miRNAs in immunity, the implication of circulating miRNAs as well as the influence of the microbiome on the miRNA response. We also review how pathogens counteract the host miRNA expression. Interestingly, bacterial non-coding RNAs regulate host gene expression and conversely eukaryotic miRNAs may regulate bacterial gene expression. Overall, the characterization of RNA regulatory networks represents an emerging theme in the field of host pathogen interactions.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1084-9521eISSN: 1096-3634DOI: 10.1016/j.semcdb.2016.06.016Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7089780
- Format
- –
- Schlagworte
- Animals, Bacteria, Bacteria - genetics, Bacteria - growth & development, Bacteria - immunology, Bacterial Infections - genetics, Bacterial Infections - immunology, Bacterial Infections - microbiology, Bacteriology, Biochemistry, Molecular Biology, Cellular Biology, Disease Resistance - genetics, Gene Expression Regulation, Gene Regulatory Networks - immunology, Genomics, Host-pathogen, Host-Pathogen Interactions - genetics, Host-Pathogen Interactions - immunology, Humans, Immunity, Innate, Life Sciences, lncRNA, Mammals, Microbiology and Parasitology, microRNA, MicroRNAs - genetics, MicroRNAs - immunology, Molecular biology, NF-kappa B - genetics, NF-kappa B - immunology, Regulatory network, RNA, Long Noncoding - genetics, RNA, Long Noncoding - immunology, Signal Transduction, Subcellular Processes