Details

Autor(en) / Beteiligte

• Rose, Angela
• Kissling, Esther
• Emborg, Hanne-Dorthe
• Larrauri, Amparo
• McMenamin, Jim
• Pozo, Francisco
• Trebbien, Ramona
• Mazagatos, Clara
• Whitaker, Heather
• Valenciano, Marta

Titel

Interim 2019/20 influenza vaccine effectiveness: six European studies, September 2019 to January 2020

Ist Teil von

• Euro surveillance : bulletin européen sur les maladies transmissibles, 2020-03, Vol.25 (10)

Ort / Verlag

Sweden: European Centre for Disease Prevention and Control

Erscheinungsjahr

2020

Quelle

MEDLINE

Beschreibungen/Notizen

• BackgroundInfluenza A(H1N1)pdm09, A(H3N2) and B viruses were co-circulating in Europe between September 2019 and January 2020.AimTo provide interim 2019/20 influenza vaccine effectiveness (VE) estimates from six European studies, covering 10 countries and both primary care and hospital settings.MethodsAll studies used the test-negative design, although there were some differences in other study characteristics, e.g. patient selection, data sources, case definitions and included age groups. Overall and influenza (sub)type-specific VE was estimated for each study using logistic regression adjusted for potential confounders.ResultsThere were 31,537 patients recruited across the six studies, of which 5,300 (17%) were cases with 5,310 infections. Most of these (4,466; 84%) were influenza A. The VE point estimates for all ages were 29% to 61% against any influenza in the primary care setting and 35% to 60% in hospitalised older adults (aged 65 years and over). The VE point estimates against A(H1N1)pdm09 (all ages, both settings) was 48% to 75%, and against A(H3N2) ranged from -58% to 57% (primary care) and -16% to 60% (hospital). Against influenza B, VE for all ages was 62% to 83% (primary care only).ConclusionsInfluenza vaccination is of continued benefit during the ongoing 2019/20 influenza season. Robust end-of-season VE estimates and genetic virus characterisation results may help understand the variability in influenza (sub)type-specific results across studies.