Details

Autor(en) / Beteiligte

• Parodi, Katia

Titel

Latest developments in in-vivo imaging for proton therapy

Ist Teil von

• British journal of radiology, 2020-03, Vol.93 (1107), p.20190787

Ort / Verlag

England: The British Institute of Radiology

Erscheinungsjahr

2020

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Owing to the favorable physical and biological properties of swift ions in matter, their application to radiation therapy for highly selective cancer treatment is rapidly spreading worldwide. To date, over 90 ion therapy facilities are operational, predominantly with proton beams, and about the same amount is under construction or planning.Over the last decades, considerable developments have been achieved in accelerator technology, beam delivery and medical physics to enhance conformation of the dose delivery to complex shaped tumor volumes, with excellent sparing of surrounding normal tissue and critical organs. Nevertheless, full clinical exploitation of the ion beam advantages is still challenged, especially by uncertainties in the knowledge of the beam range in the actual patient anatomy during the fractionated course of treatment, thus calling for continued multidisciplinary research in this rapidly emerging field.This contribution will review latest developments aiming to image the patient with the same beam quality as for therapy prior to treatment, and to visualize the treatment delivery by exploiting irradiation-induced physical emissions, with different level of maturity from proof-of-concept studies in phantoms and first studies up to clinical testing and initial clinical evaluation.