Details

Autor(en) / Beteiligte

• Yoshii, Yukie
• Tashima, Hideaki
• Iwao, Yuma
• Yoshida, Eiji
• Wakizaka, Hidekatsu
• Akamatsu, Go
• Yamaya, Taiga
• Matsumoto, Hiroki
• Yoshimoto, Mitsuyoshi
• Igarashi, Chika
• Hihara, Fukiko
• Tachibana, Tomoko
• Zhang, Ming-Rong
• Nagatsu, Kotaro
• Sugyo, Aya
• Tsuji, Atsushi B
• Higashi, Tatsuya

Titel

Immuno-OpenPET: a novel approach for early diagnosis and image-guided surgery for small resectable pancreatic cancer

Ist Teil von

• Scientific reports, 2020-03, Vol.10 (1), p.4143-4143, Article 4143

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2020

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Pancreatic cancer (PC) has a poor prognosis owing to difficulties in the diagnosis of resectable PC at early stages. Several clinical studies have indicated that the detection and surgery of small resectable PC (<1 cm) can significantly improve survival; however, imaging diagnosis and accurate resection of small PC remain challenging. Here, we report the feasibility of "immuno-OpenPET" as a novel approach enabling not only early diagnosis but also image-guided surgery, using a small (<1 cm) resectable PC orthotopic xenograft mouse model. For immuno-OpenPET, we utilized our original OpenPET system, which enables high-resolution positron emission tomography (PET) imaging with depth-of-interaction detectors, as well as real-time image-guided surgery, by arranging the detectors to create an open space for surgery and accelerating the image reconstruction process by graphics processing units. For immuno-OpenPET, Cu-labeled anti-epidermal growth factor receptor antibody cetuximab was intraperitoneally administered into mice. It clearly identified PC tumors ≥3 mm. In contrast, neither OpenPET with intravenous-administered Cu-cetuximab nor intraperitoneal/intravenous-administered F-FDG (a traditional PET probe) could detect PC in this model. Immuno-OpenPET-guided surgery accurately resected small PC in mice and achieved significantly prolonged survival. This technology could provide a novel diagnostic and therapeutic strategy for small resectable PC to improve patient survival.