Details

Autor(en) / Beteiligte

• Su, Hao
• Wang, Feihu
• Ran, Wei
• Zhang, Weijie
• Dai, Wenbing
• Wang, Han
• Anderson, Caleb F.
• Wang, Zongyuan
• Zheng, Chao
• Zhang, Pengcheng
• Li, Yaping
• Cui, Honggang

Titel

The role of critical micellization concentration in efficacy and toxicity of supramolecular polymers

Ist Teil von

• Proceedings of the National Academy of Sciences - PNAS, 2020-03, Vol.117 (9), p.4518-4526

Ort / Verlag

United States: National Academy of Sciences

Erscheinungsjahr

2020

Quelle

MEDLINE

Beschreibungen/Notizen

• The inception and development of supramolecular chemistry have provided a vast library of supramolecular structures and materials for improved practice of medicine. In the context of therapeutic delivery, while supramolecular nanostructures offer a wide variety of morphologies as drug carriers for optimized targeting and controlled release, concerns are often raised as to how their morphological stability and structural integrity impact their in vivo performance. After intravenous (i.v.) administration, the intrinsic reversible and dynamic feature of supramolecular assemblies may lead them to dissociate upon plasma dilution to a concentration below their critical micellization concentration (CMC). As such, CMC represents an important characteristic for supramolecular biomaterials design, but its pharmaceutical role remains elusive. Here, we report the design of a series of self-assembling prodrugs (SAPDs) that spontaneously associate in aqueous solution into supramolecular polymers (SPs)with varying CMCs. Two hydrophobic camptothecin (CPT) molecules were conjugated onto oligoethyleneglycol (OEG)-decorated segments with various OEG repeat numbers (2, 4, 6, 8). Our studies show that the lower the CMC, the lower the maximum tolerated dose (MTD) in rodents. When administrated at the same dosage of 10 mg/kg (CPT equivalent), SAPD 1, the one with the lowest CMC, shows the best efficacy in tumor suppression. These observations can be explained by the circulation and dissociation of SAPD SPs and the difference in molecular and supramolecular distribution between excretion and organ uptake. We believe these findings offer important insight into the role of supramolecular stability in determining their therapeutic index and in vivo efficacy.