Details

Autor(en) / Beteiligte

• Badir, Shorouk O
• Sim, Jaehoon
• Billings, Katelyn
• Csakai, Adam
• Zhang, Xuange
• Dong, Weizhe
• Molander, Gary A

Titel

Multifunctional Building Blocks Compatible with Photoredox-Mediated Alkylation for DNA-Encoded Library Synthesis

Ist Teil von

• Organic letters, 2020-02, Vol.22 (3), p.1046-1051

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2020

Quelle

MEDLINE

Beschreibungen/Notizen

• DNA-encoded library (DEL) technology has emerged as a novel interrogation modality for ligand discovery in the pharmaceutical industry. Given the increasing demand for a higher proportion of C­(sp3)-hybridized centers in DEL platforms, a photoredox-mediated cross-coupling and defluorinative alkylation process is introduced using commercially available alkyl bromides and structurally diverse α-silylamines. Notably, no protecting group strategies for amines are necessary for the incorporation of a variety of amino-acid-based organosilanes, providing crucial branching points for further derivatization.