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Japan society of clinical oncology/Japanese society of medical oncology-led clinical recommendations on the diagnosis and use of tropomyosin receptor kinase inhibitors in adult and pediatric patients with neurotrophic receptor tyrosine kinase fusion-positive advanced solid tumors, cooperated by the Japanese society of pediatric hematology/oncology
Ist Teil von
International journal of clinical oncology, 2020-03, Vol.25 (3), p.403-417
Ort / Verlag
Singapore: Springer Singapore
Erscheinungsjahr
2020
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
Background
The development of novel antitumor agents and accompanying biomarkers has improved survival across several tumor types. Previously, we published provisional clinical opinion for the diagnosis and use of immunotherapy in patients with deficient DNA mismatch repair tumors. Recently, efficacy of tropomyosin receptor kinase inhibitors against
neurotrophic receptor tyrosine kinase (NTRK)
fusion gene-positive advanced solid tumors have been established as the second tumor-agnostic treatment, making it necessary to develop the guideline prioritized for these patients.
Methods
Clinical questions regarding medical care were formulated for patients with
NTRK
-positive advanced solid tumors. Relevant publications were searched by PubMed and Cochrane Database. Critical publications and conference reports were added manually. Systematic reviews were performed for each clinical question for the purpose of developing clinical recommendations. The committee members identified by Japan Society of Clinical Oncology (JSCO) and Japanese Society of Medical Oncology (JSMO) voted to determine the level of each recommendation considering the strength of evidence, expected risks and benefits to patients, and other related factors. Thereafter, a peer review by experts nominated from JSCO, JSMO, and Japanese Society of Pediatric Hematology/Oncology, and the public comments among all Societies’ members was done.
Results
The current guideline describes 3 clinical questions and 15 recommendations for whom, when, and how
NTRK
fusion should be tested, and what is recommended for patients with
NTRK
fusion-positive advanced solid tumors.
Conclusion
In the
NTRK
guideline, the committee proposed 15 recommendations for performing
NTRK
testing properly to select patients who are likely to benefit from tropomyosin receptor kinase inhibitors.