Chembiochem : a European journal of chemical biology, 2020-01, Vol.21 (1-2), p.45-52
2020
Details
- Autor(en) / Beteiligte
- Titel
- Small‐Molecule Inhibition of Glucose Transporters GLUT‐1–4
- Ist Teil von
- Chembiochem : a European journal of chemical biology, 2020-01, Vol.21 (1-2), p.45-52
- Ort / Verlag
- Germany: Wiley Subscription Services, Inc
- Erscheinungsjahr
- 2020
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Glucose addiction is observed in cancer and other diseases that are associated with hyperproliferation. The development of compounds that restrict glucose supply and decrease glycolysis has great potential for the development of new therapeutic approaches. Addressing facilitative glucose transporters (GLUTs), which are often upregulated in glucose‐dependent cells, is therefore of particular interest. This article reviews a selection of potent, isoform‐selective GLUT inhibitors and their biological characterization. Potential therapeutic applications of GLUT inhibitors in oncology and other diseases that are linked to glucose addiction are discussed. Targeting aerobic glycolysis by means of glucose uptake inhibition may be a new approach for the treatment of proliferative diseases such as cancer and inflammatory disorders. This Minireview provides an overview of the most potent and advanced inhibitors of glucose uptake by glucose transporters GLUT‐1–4 and sheds light on their potential for therapeutic applications.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1439-4227eISSN: 1439-7633DOI: 10.1002/cbic.201900544Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7004114
- Format
- –
- Schlagworte
- Addictions, antitumor agents, cancer, drug discovery, Glucose, Glucose - antagonists & inhibitors, Glucose - metabolism, Glucose Transporter Type 1 - antagonists & inhibitors, Glucose Transporter Type 1 - chemistry, Glucose Transporter Type 2 - antagonists & inhibitors, Glucose Transporter Type 2 - chemistry, Glucose Transporter Type 3 - antagonists & inhibitors, Glucose Transporter Type 3 - chemistry, Glucose Transporter Type 4 - antagonists & inhibitors, Glucose Transporter Type 4 - chemistry, GLUT inhibitors, Glycolysis, Humans, Inhibitors, metabolism, Minireview, Minireviews, Models, Molecular, Molecular Structure, Oncology, Small Molecule Libraries - chemistry, Small Molecule Libraries - pharmacology, Therapeutic applications