Details

Autor(en) / Beteiligte

• Bleecker, Eugene R
• Menzies-Gow, Andrew N
• Price, David B
• Bourdin, Arnaud
• Sweet, Stephen
• Martin, Amber L
• Alacqua, Marianna
• Tran, Trung N

Titel

Systematic Literature Review of Systemic Corticosteroid Use for Asthma Management

Ist Teil von

• American journal of respiratory and critical care medicine, 2020-02, Vol.201 (3), p.276-293

Ort / Verlag

United States: American Thoracic Society

Erscheinungsjahr

2020

Quelle

MEDLINE

Beschreibungen/Notizen

• Systemic corticosteroid use to manage uncontrolled asthma and its associated healthcare burden may account for important health-related adverse effects. We conducted a systematic literature review to investigate the real-world extent and burden of systemic corticosteroid use in asthma. We searched MEDLINE and Embase databases to identify English-language articles published in 2010-2017, using search terms for asthma with keywords for oral corticosteroids and systemic corticosteroids. Observational studies, prescription database analyses, economic analyses, and surveys on oral/systemic corticosteroid use in children (>5 yr old), adolescents (12-17 yr old), and adults with asthma were included. We identified and reviewed 387 full-text articles, and our review included data from 139 studies. The included studies were conducted in Europe, North America, and Asia. Overall, oral/systemic corticosteroids were commonly used for asthma management and were more frequently used in patients with severe asthma than in those with milder disease. Long-term oral/systemic corticosteroid use was, in general, less frequent than short-term use. Compared with no use, long-term and repeated short-term oral/systemic corticosteroid use were associated with an increased risk of acute and chronic adverse events, even when doses were comparatively low. Greater oral/systemic corticosteroid exposure was also associated with increased costs and healthcare resource use. This review provides a comprehensive overview of oral/systemic corticosteroid use and associated adverse events for patients with all degrees of asthma severity and exposure duration. We report that oral/systemic corticosteroid use is prevalent in asthma management, and the risks of acute and chronic complications increase with the cumulative oral corticosteroid dosage.