Details

Autor(en) / Beteiligte

• Tan, Shutang
• Abas, Melinda
• Verstraeten, Inge
• Glanc, Matouš
• Molnár, Gergely
• Hajný, Jakub
• Lasák, Pavel
• Petřík, Ivan
• Russinova, Eugenia
• Petrášek, Jan
• Novák, Ondřej
• Pospíšil, Jiří
• Friml, Jiří

Titel

Salicylic Acid Targets Protein Phosphatase 2A to Attenuate Growth in Plants

Ist Teil von

• Current biology, 2020-02, Vol.30 (3), p.381-395.e8

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2020

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Plants, like other multicellular organisms, survive through a delicate balance between growth and defense against pathogens. Salicylic acid (SA) is a major defense signal in plants, and the perception mechanism as well as downstream signaling activating the immune response are known. Here, we identify a parallel SA signaling that mediates growth attenuation. SA directly binds to A subunits of protein phosphatase 2A (PP2A), inhibiting activity of this complex. Among PP2A targets, the PIN2 auxin transporter is hyperphosphorylated in response to SA, leading to changed activity of this important growth regulator. Accordingly, auxin transport and auxin-mediated root development, including growth, gravitropic response, and lateral root organogenesis, are inhibited. This study reveals how SA, besides activating immunity, concomitantly attenuates growth through crosstalk with the auxin distribution network. Further analysis of this dual role of SA and characterization of additional SA-regulated PP2A targets will provide further insights into mechanisms maintaining a balance between growth and defense. [Display omitted] •SA modulates root development independently of NPR1-mediated canonical signaling•SA attenuates growth through crosstalk with the auxin transport network•SA upregulates the phosphorylation status of PIN auxin efflux carriers through PP2A•SA directly targets A subunits of PP2A, inhibiting the activity of the complex Besides the canonical role in immunity, the defense hormone salicylic acid also shapes plant growth and development. Tan et al. show that salicylic acid regulates Arabidopsis growth through directly binding to A subunits of the PP2A enzyme and thereby modulating its activity.