Details

Autor(en) / Beteiligte

• Rivera-Tarazona, L K
• Bhat, V D
• Kim, H
• Campbell, Z T
• Ware, T H

Titel

Shape-morphing living composites

Ist Teil von

• Science advances, 2020-01, Vol.6 (3), p.eaax8582

Ort / Verlag

United States: American Association for the Advancement of Science

Erscheinungsjahr

2020

Quelle

MEDLINE

Beschreibungen/Notizen

• This work establishes a means to exploit genetic networks to create living synthetic composites that change shape in response to specific biochemical or physical stimuli. Baker's yeast embedded in a hydrogel forms a responsive material where cellular proliferation leads to a controllable increase in the composite volume of up to 400%. Genetic manipulation of the yeast enables composites where volume change on exposure to l-histidine is 14× higher than volume change when exposed to d-histidine or other amino acids. By encoding an optogenetic switch into the yeast, spatiotemporally controlled shape change is induced with pulses of dim blue light (2.7 mW/cm ). These living, shape-changing materials may enable sensors or medical devices that respond to highly specific cues found within a biological milieu.