Details

Autor(en) / Beteiligte

• Hataye, Jason M.
• Casazza, Joseph P.
• Best, Katharine
• Liang, C. Jason
• Immonen, Taina T.
• Ambrozak, David R.
• Darko, Samuel
• Henry, Amy R.
• Laboune, Farida
• Maldarelli, Frank
• Douek, Daniel C.
• Hengartner, Nicolas W.
• Yamamoto, Takuya
• Keele, Brandon F.
• Perelson, Alan S.
• Koup, Richard A.

Titel

Principles Governing Establishment versus Collapse of HIV-1 Cellular Spread

Ist Teil von

• Cell host & microbe, 2019-12, Vol.26 (6), p.748-763.e20

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2019

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• A population at low census might go extinct or instead transition into exponential growth to become firmly established. Whether this pivotal event occurs for a within-host pathogen can be the difference between health and illness. Here, we define the principles governing whether HIV-1 spread among cells fails or becomes established by coupling stochastic modeling with laboratory experiments. Following ex vivo activation of latently infected CD4 T cells without de novo infection, stochastic cell division and death contributes to high variability in the magnitude of initial virus release. Transition to exponential HIV-1 spread often fails due to release of an insufficient amount of replication-competent virus. Establishment of exponential growth occurs when virus produced from multiple infected cells exceeds a critical population size. We quantitatively define the crucial transition to exponential viral spread. Thwarting this process would prevent HIV transmission or rebound from the latent reservoir. [Display omitted] •Transition from latency to exponential HIV growth is covert, rare, and stochastic•After latency disruption, the initial HIV release amount is highly variable•If the initial virus release exceeds a critical threshold, exponential spread ensues•Coupling experimental and computational approaches can define the origin of HIV rebound Transition to exponential growth is a canonical mode of population establishment. For HIV spread among cells following latency disruption, Hataye et al. discover that this crucial transition occurs if the initial virus release exceeds a critical growth threshold, which can trigger HIV rebound.