Details

Autor(en) / Beteiligte

• Cosentino, Nicola
• Genovese, Stefano
• Campodonico, Jeness
• Bonomi, Alice
• Lucci, Claudia
• Milazzo, Valentina
• Moltrasio, Marco
• Biondi, Maria Luisa
• Riggio, Daniela
• Veglia, Fabrizio
• Ceriani, Roberto
• Celentano, Katia
• De Metrio, Monica
• Rubino, Mara
• Bartorelli, Antonio L
• Marenzi, Giancarlo

Titel

High-Sensitivity C-Reactive Protein and Acute Kidney Injury in Patients with Acute Myocardial Infarction: A Prospective Observational Study

Ist Teil von

• Journal of clinical medicine, 2019-12, Vol.8 (12), p.2192

Ort / Verlag

Switzerland: MDPI

Erscheinungsjahr

2019

Quelle

EZB Free E-Journals

Beschreibungen/Notizen

• Accumulating evidence suggests that inflammation plays a key role in acute kidney injury (AKI) pathogenesis. We explored the relationship between high-sensitivity C-reactive protein (hs-CRP) and AKI in acute myocardial infarction (AMI). We prospectively included 2,063 AMI patients in whom hs-CRP was measured at admission. AKI incidence and a clinical composite of in-hospital death, cardiogenic shock, and acute pulmonary edema were the study endpoints. . Two-hundred-thirty-four (11%) patients developed AKI. hs-CRP levels were higher in AKI patients (45 ± 87 vs. 16 ± 41 mg/L; < 0.0001). The incidence and severity of AKI, as well as the rate of the composite endpoint, increased in parallel with hs-CRP quartiles ( for trend <0.0001 for all comparisons). A significant correlation was found between hs-CRP and the maximal increase of serum creatinine (R = 0.23; < 0.0001). The AUC of hs-CRP for AKI prediction was 0.69 ( < 0.001). At reclassification analysis, addition of hs-CRP allowed to properly reclassify 14% of patients when added to creatinine and 8% of patients when added to a clinical model. In AMI, admission hs-CRP is closely associated with AKI development and severity, and with in-hospital outcomes. Future research should focus on whether prophylactic renal strategies in patients with high hs-CRP might prevent AKI and improve outcome.