Details

Autor(en) / Beteiligte

• Chamberlain, Philip P
• D’Agostino, Laura A
• Ellis, J. Michael
• Hansen, Joshua D
• Matyskiela, Mary E
• McDonald, Joseph J
• Riggs, Jennifer R
• Hamann, Lawrence G

Titel

Evolution of Cereblon-Mediated Protein Degradation as a Therapeutic Modality

Ist Teil von

• ACS medicinal chemistry letters, 2019-12, Vol.10 (12), p.1592-1602

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2019

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Many cellular processes and pathways are mediated by the regulation of protein–protein complexes. For example, E3 ubiquitin ligases recruit substrate proteins and transfer a ubiquitin tag to target those proteins for destruction by the proteasome. It has now been shown that this cellular process for protein destruction can be redirected by small molecules in both laboratory and clinical settings. This presents a new paradigm in drug discovery, enabling the rapid removal of target proteins linked to disease. In this Innovations review, we will describe the work done on cereblon as a case study on the different strategies available for targeted protein degradation.