Proceedings of the National Academy of Sciences - PNAS, 2019-12, Vol.116 (50), p.25250-25259
2019
Details
- Autor(en) / Beteiligte
- Titel
- Distinct metabolic adaptation of liver circadian pathways to acute and chronic patterns of alcohol intake
- Ist Teil von
- Proceedings of the National Academy of Sciences - PNAS, 2019-12, Vol.116 (50), p.25250-25259
- Ort / Verlag
- United States: National Academy of Sciences
- Erscheinungsjahr
- 2019
- Link zum Volltext
- Quelle
- Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
- Beschreibungen/Notizen
- Binge drinking and chronic exposure to ethanol contribute to alcoholic liver diseases (ALDs). A potential link between ALDs and circadian disruption has been observed, though how different patterns of alcohol consumption differentially impact hepatic circadian metabolism remains virtually unexplored. Using acute versus chronic ethanol feeding, we reveal differential reprogramming of the circadian transcriptome in the liver. Specifically, rewiring of diurnal SREBP transcriptional pathway leads to distinct hepatic signatures in acetyl-CoA metabolism that are translated into the subcellular patterns of protein acetylation. Thus, distinct drinking patterns of alcohol dictate differential adaptation of hepatic circadian metabolism.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0027-8424eISSN: 1091-6490DOI: 10.1073/pnas.1911189116Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6911183
- Format
- –
- Schlagworte
- Acetylation, Adaptation, Alcohol Drinking - genetics, Alcohol Drinking - metabolism, Alcohol use, Alcoholic beverages, Animals, Binge drinking, Biological Sciences, Circadian Rhythm, Circadian rhythms, Disruption, Diurnal, Drinking behavior, Ethanol, Ethanol - metabolism, Gene expression, Humans, Liver, Liver - metabolism, Liver diseases, Male, Metabolism, Mice, Inbred C57BL, Sterol Regulatory Element Binding Proteins - genetics, Sterol Regulatory Element Binding Proteins - metabolism, Sterol regulatory element-binding protein, Transcription, Transcriptome