Details

Autor(en) / Beteiligte

• Navarro Quiroz, Elkin
• Chavez-Estrada, Valeria
• Macias-Ochoa, Karime
• Ayala-Navarro, María Fernanda
• Flores-Aguilar, Aniyensy Sarai
• Morales-Navarrete, Francisco
• de la Cruz Lopez, Fernando
• Gomez Escorcia, Lorena
• Musso, Carlos G
• Aroca Martinez, Gustavo
• Gonzales Torres, Henry
• Diaz Perez, Anderson
• Cadena Bonfanti, Andres
• Sarmiento Gutierrez, Joany
• Meza, Jainy
• Diaz Arroyo, Esperanza
• Bello Lemus, Yesit
• Ahmad, Mostapha
• Navarro Quiroz, Roberto

Titel

Epigenetic Mechanisms and Posttranslational Modifications in Systemic Lupus Erythematosus

Ist Teil von

• International journal of molecular sciences, 2019-11, Vol.20 (22), p.5679

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2019

Quelle

EZB-FREE-00999 freely available EZB journals

Beschreibungen/Notizen

• The complex physiology of eukaryotic cells is regulated through numerous mechanisms, including epigenetic changes and posttranslational modifications. The wide-ranging diversity of these mechanisms constitutes a way of dynamic regulation of the functionality of proteins, their activity, and their subcellular localization as well as modulation of the differential expression of genes in response to external and internal stimuli that allow an organism to respond or adapt to accordingly. However, alterations in these mechanisms have been evidenced in several autoimmune diseases, including systemic lupus erythematosus (SLE). The present review aims to provide an approach to the current knowledge of the implications of these mechanisms in SLE pathophysiology.