Details

Autor(en) / Beteiligte

• Pitta, Maira Galdino da Rocha
• de Melo Rego, Moacyr Jesus Barreto
• Lucena-Araujo, Antônio Roberto
• Martins, Mário Rino
• Cordeiro, Marina Ferraz
• de Souza Albuquerque, Mário Sérgio
• Quirino, Michael Williams Leal
• de Barros Albuquerque, Amanda Pinheiro
• da Silva Filho, Antônio Felix
• de Souza, Maria de Fátima Deodato
• Pitta, Ivan da Rocha
• Knaś, Małgorzata
• Małgorzata Knaś

Titel

Overexpression of UDP-Glucose 4-Epimerase Is Associated with Differentiation Grade of Gastric Cancer

Ist Teil von

• Disease markers, 2019, Vol.2019 (2019), p.1-5

Ort / Verlag

Cairo, Egypt: Hindawi Publishing Corporation

Erscheinungsjahr

2019

Quelle

Electronic Journals Library

Beschreibungen/Notizen

• The UDP-glucose 4-epimerase (GALE) is a glycosyltransferase, which acts on protein and lipid glycosylation in normal and neoplastic cells. This study is aimed at investigating the differential tissue expression of GALE and its possible association with clinical-pathological parameters and the outcome of gastric adenocarcinoma patients. Seventy-one patients were evaluated in relation to GALE expression by immunohistochemistry. Our results showed that 48 (67.6%) patients were GALE positive and 23 (32.4%) negative. Positive staining was present on well-differentiated and moderate-differentiated histological grade of gastric adenocarcinomas (p<0.0001). There was no significant association with outcome parameters (p>0.05). Besides that, our results corroborated with the validation cohort analysis, where the expression of GALE mRNA was also associated with the histological grade (p<0.001). These results suggest a possible use of this enzyme as a biomarker for well and moderately differentiated tumors.