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BibTeX
Analysis of lesions in patients with unilateral tactile agnosia using cytoarchitectonic probabilistic maps
Human brain mapping, 2009-05, Vol.30 (5), p.1444-1456
Hömke, Lars
Amunts, Katrin
Bönig, Lutz
Fretz, Christian
Binkofski, Ferdinand
Zilles, Karl
Weder, Bruno
2009
Details
Autor(en) / Beteiligte
Hömke, Lars
Amunts, Katrin
Bönig, Lutz
Fretz, Christian
Binkofski, Ferdinand
Zilles, Karl
Weder, Bruno
Titel
Analysis of lesions in patients with unilateral tactile agnosia using cytoarchitectonic probabilistic maps
Ist Teil von
Human brain mapping, 2009-05, Vol.30 (5), p.1444-1456
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2009
Link zum Volltext
Quelle
Free E-Journal (出版社公開部分のみ)
Beschreibungen/Notizen
We propose a novel methodical approach to lesion analyses involving high‐resolution MR images in combination with probabilistic cytoarchitectonic maps. 3D‐MR images of the whole brain and the manually segmented lesion mask are spatially normalized to the reference brain of a stereotaxic probabilistic cytoarchitectonic atlas using a multiscale registration algorithm based on an elastic model. The procedure is demonstrated in three patients suffering from aperceptive tactile agnosia of the right hand due to chronic infarction of the left parietal cortex. Patient 1 presents a lesion in areas of the postcentral sulcus, Patient 3 in areas of the superior parietal lobule and adjacent intraparietal sulcus, and Patient 2 lesions in both regions. On the basis of neurobehavioral data, we conjectured degradation of sequential elementary sensory information processing within the postcentral gyrus, impeding texture recognition in Patients 1 and 2, and disturbed kinaesthetic information processing in the posterior parietal lobe, causing degraded shape recognition in the patients 2 and 3. The involvement of Brodmann areas 4a, 4p, 3a, 3b, 1, 2, and areas IP1 and IP2 of the intraparietal sulcus was assessed in terms of the voxel overlap between the spatially transformed lesion masks and the 50%‐isocontours of the cytoarchitectonic maps. The disruption of the critical cytoarchitectonic areas and the impaired subfunctions, texture and shape recognition, relate as conjectured above. We conclude that the proposed method represents a promising approach to hypothesis‐driven lesion analyses, yielding lesion‐function correlates based on a cytoarchitectonic model. Finally, the lesion‐function correlates are validated by functional imaging reference data. Hum Brain Mapp 2009. © 2008 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 1065-9471
eISSN: 1097-0193
DOI: 10.1002/hbm.20617
Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6870829
Format
–
Schlagworte
Adult
,
Aged
,
Agnosia - pathology
,
Agnosia - physiopathology
,
Algorithms
,
Biological and medical sciences
,
Brain Mapping
,
cytoarchitectonic probabilistic maps
,
Discrimination (Psychology) - physiology
,
double dissociation
,
Female
,
Functional Laterality - physiology
,
Humans
,
Imaging, Three-Dimensional - methods
,
Investigative techniques, diagnostic techniques (general aspects)
,
lesion analysis
,
Magnetic Resonance Imaging - methods
,
Male
,
Medical sciences
,
Middle Aged
,
Nervous system
,
Neurology
,
Neuropsychological Tests
,
Parietal Lobe - pathology
,
Physical Stimulation - methods
,
Probability
,
Radiodiagnosis. Nmr imagery. Nmr spectrometry
,
shape recognition
,
Stereotaxic Techniques
,
tactile agnosia
,
texture recognition
,
Touch - physiology
,
Vascular diseases and vascular malformations of the nervous system
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