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Default mode network abnormalities in mesial temporal lobe epilepsy: A study combining fMRI and DTI
Human brain mapping, 2011-06, Vol.32 (6), p.883-895
Liao, Wei
Zhang, Zhiqiang
Pan, Zhengyong
Mantini, Dante
Ding, Jurong
Duan, Xujun
Luo, Cheng
Wang, Zhengge
Tan, Qifu
Lu, Guangming
Chen, Huafu
2011
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Liao, Wei
Zhang, Zhiqiang
Pan, Zhengyong
Mantini, Dante
Ding, Jurong
Duan, Xujun
Luo, Cheng
Wang, Zhengge
Tan, Qifu
Lu, Guangming
Chen, Huafu
Titel
Default mode network abnormalities in mesial temporal lobe epilepsy: A study combining fMRI and DTI
Ist Teil von
Human brain mapping, 2011-06, Vol.32 (6), p.883-895
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2011
Quelle
Wiley-Blackwell Journals
Beschreibungen/Notizen
Studies of in mesial temporal lobe epilepsy (mTLE) patients with hippocampal sclerosis (HS) have reported reductions in both functional and structural connectivity between hippocampal structures and adjacent brain regions. However, little is known about the connectivity among the default mode network (DMN) in mTLE. Here, we hypothesized that both functional and structural connectivity within the DMN were disturbed in mTLE. To test this hypothesis, functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) were applied to examine the DMN connectivity of 20 mTLE patients, and 20 gender‐ and age‐matched healthy controls. Combining these two techniques, we explored the changes in functional (temporal correlation coefficient derived from fMRI) and structural (path length and connection density derived from DTI tractography) connectivity of the DMN. Compared to the controls, we found that both functional and structural connectivity were significantly decreased between the posterior cingulate cortex (PCC)/precuneus (PCUN) and bilateral mesial temporal lobes (mTLs) in patients. No significant between‐group difference was found between the PCC/PCUN and medial prefrontal cortex (mPFC). In addition, functional connectivity was found to be correlated with structural connectivity in two pairwise regions, namely between the PCC/PCUN and bilateral mTLs, respectively. Our results suggest that the decreased functional connectivity within the DMN in mTLE may be a consequence of the decreased connection density underpinning the degeneration of structural connectivity. Hum Brain Mapp, 2011. © 2010 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 1065-9471, 1097-0193
eISSN: 1097-0193
DOI: 10.1002/hbm.21076
Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6870458
Format
–
Schlagworte
Adolescent
,
Adult
,
Biological and medical sciences
,
Brain - physiopathology
,
Brain Mapping - methods
,
default mode network
,
Diffusion Tensor Imaging
,
Epilepsy, Temporal Lobe - physiopathology
,
Female
,
fiber tractography
,
functional connectivity
,
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
,
hippocampal sclerosis
,
Humans
,
Image Interpretation, Computer-Assisted
,
Investigative techniques, diagnostic techniques (general aspects)
,
Magnetic Resonance Imaging
,
Male
,
Medical sciences
,
mesial temporal lobe epilepsy
,
Middle Aged
,
Nervous system
,
Nervous system (semeiology, syndromes)
,
Neural Pathways - physiopathology
,
Neurology
,
Radiodiagnosis. Nmr imagery. Nmr spectrometry
,
Young Adult
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