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Frontal and posterior cingulate metabolic impairment in the behavioral variant of frontotemporal dementia with impaired autonoetic consciousness
Human brain mapping, 2012-06, Vol.33 (6), p.1268-1278
Bastin, Christine
Feyers, Dorothée
Souchay, Céline
Guillaume, Bénédicte
Pepin, Jean-Louis
Lemaire, Christian
Degueldre, Christian
Collette, Fabienne
Salmon, Eric
2012
Details
Autor(en) / Beteiligte
Bastin, Christine
Feyers, Dorothée
Souchay, Céline
Guillaume, Bénédicte
Pepin, Jean-Louis
Lemaire, Christian
Degueldre, Christian
Collette, Fabienne
Salmon, Eric
Titel
Frontal and posterior cingulate metabolic impairment in the behavioral variant of frontotemporal dementia with impaired autonoetic consciousness
Ist Teil von
Human brain mapping, 2012-06, Vol.33 (6), p.1268-1278
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2012
Link zum Volltext
Quelle
Wiley Online Library - AutoHoldings Journals
Beschreibungen/Notizen
Although memory dysfunction is not a prominent feature of the behavioral variant of frontotemporal dementia (bv‐FTD), there is evidence of specific deficits of episodic memory in these patients. They also have problems monitoring their memory performance. The objective of the present study was to explore the ability to consciously retrieve own encoding of the context of events (autonoetic consciousness) and the ability to monitor memory performance using feeling‐of‐knowing (FOK) in bv‐FTD. Analyses of the patients' cerebral metabolism (FDG‐PET) allowed an examination of whether impaired episodic memory in bv‐FTD is associated with the frontal dysfunction characteristic of the pathology or a dysfunction of memory‐specific regions pertaining to Papez's circuit. Data were obtained from eight bv‐FTD patients and 26 healthy controls. Autonoetic consciousness was evaluated by Remember responses during the recognition memory phase of the FOK experiment. As a group, bv‐FTD patients demonstrated a decline in autonoetic consciousness and FOK accuracy at the chance level. While memory monitoring was impaired in most (seven) patients, four bv‐FTD participants had individual impairment of autonoetic consciousness. They specifically showed reduced metabolism in the anterior medial prefrontal cortex, the left dorsolateral prefrontal cortex (near the superior frontal sulcus), parietal regions, and the posterior cingulate cortex. These findings were tentatively interpreted by considering the role of the metabolically impaired brain regions in self‐referential processes, suggesting that the bv‐FTD patients' problem consciously retrieving episodic memories may stem at least partly from deficient access to and maintenance/use of information about the self. Frontal and posterior cingulate metabolic impairment in the behavioral variant of frontotemporal dementia with impaired autonoetic consciousness Hum Brain Mapp, 2011. © 2011 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 1065-9471, 1097-0193
eISSN: 1097-0193
DOI: 10.1002/hbm.21282
Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6870238
Format
–
Schlagworte
Aged
,
Aged, 80 and over
,
Attention - physiology
,
autonoetic consciousness
,
Awareness - physiology
,
Biochemistry and metabolism
,
Biological and medical sciences
,
Brain Mapping
,
Central nervous system
,
Choice Behavior - physiology
,
cingulate cortex
,
Consciousness - physiology
,
episodic memory
,
FDG-PET
,
Female
,
FOK
,
Frontal Lobe - diagnostic imaging
,
Frontal Lobe - metabolism
,
Frontal Lobe - physiopathology
,
frontotemporal dementia
,
Frontotemporal Dementia - diagnostic imaging
,
Frontotemporal Dementia - metabolism
,
Frontotemporal Dementia - physiopathology
,
Frontotemporal Dementia - psychology
,
Fundamental and applied biological sciences. Psychology
,
Gyrus Cinguli - diagnostic imaging
,
Gyrus Cinguli - metabolism
,
Gyrus Cinguli - physiopathology
,
Humans
,
Investigative techniques, diagnostic techniques (general aspects)
,
Male
,
Medical sciences
,
Memory - physiology
,
Middle Aged
,
monitoring
,
Nervous system
,
Neuropsychological Tests
,
Neurosciences & behavior
,
Neurosciences & comportement
,
Radiodiagnosis. Nmr imagery. Nmr spectrometry
,
Radionuclide Imaging
,
Sciences sociales & comportementales, psychologie
,
Social & behavioral sciences, psychology
,
Vertebrates: nervous system and sense organs
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