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Cortical plasticity is preserved in nondemented older individuals with severe ischemic small vessel disease
Human brain mapping, 2013-06, Vol.34 (6), p.1464-1476
List, Jonathan
Duning, Thomas
Kürten, Julia
Deppe, Michael
Wilbers, Eike
Flöel, Agnes
2013
Details
Autor(en) / Beteiligte
List, Jonathan
Duning, Thomas
Kürten, Julia
Deppe, Michael
Wilbers, Eike
Flöel, Agnes
Titel
Cortical plasticity is preserved in nondemented older individuals with severe ischemic small vessel disease
Ist Teil von
Human brain mapping, 2013-06, Vol.34 (6), p.1464-1476
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2013
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
Ischemic small vessel disease (SVD) is a common finding on routine scans in older people, but cognitive sequelae vary considerably. To improve understanding of mechanisms underlying decline or preservation of cognitive function in this condition, we assessed cognition and cortical plasticity in 20 elderly subjects with severe SVD and 20 age‐matched controls without SVD, as rated on conventional MRI. Cognitive status was determined with a neuropsychological test battery, cortical plasticity induced with a paired associative stimulation protocol. Microstructural white matter changes were further analyzed for fractional anisotrophy using diffusion tensor imaging. We found that cortical plasticity as well as memory functions were preserved in severe SVD, while executive functions showed trendwise or significant decreases. Within the SVD group, lower white matter integrity in parahippocampal regions and posterior parts of the corpus callosum was associated with larger cortical plasticity, an association not seen for prefrontal white matter tracts. Enhanced cortical plasticity in subjects with lower white matter integrity in memory‐relevant areas might thus indicate a compensatory mechanism to counteract memory decline in severe SVD. Hum Brain Mapp, 2013. © 2012 Wiley Periodicals, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 1065-9471
eISSN: 1097-0193
DOI: 10.1002/hbm.22003
Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6870013
Format
–
Schlagworte
Aged
,
Anisotropy
,
Biological and medical sciences
,
Brain Ischemia - complications
,
Brain Ischemia - pathology
,
Brain Ischemia - physiopathology
,
Cerebral Cortex - pathology
,
Cerebral Cortex - physiology
,
Cognition - physiology
,
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
,
Diffusion Magnetic Resonance Imaging
,
diffusion tensor imaging
,
Female
,
Humans
,
Investigative techniques, diagnostic techniques (general aspects)
,
Male
,
Medical sciences
,
Middle Aged
,
Nervous system
,
Neurology
,
Neuronal Plasticity - physiology
,
Neuropsychological Tests
,
paired associative stimulation
,
Radiodiagnosis. Nmr imagery. Nmr spectrometry
,
Transcranial Magnetic Stimulation
,
white matter hyperintensities
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