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The effects of methylphenidate on whole brain intrinsic functional connectivity
Human brain mapping, 2014-11, Vol.35 (11), p.5379-5388
Mueller, Sophia
Costa, Anna
Keeser, Daniel
Pogarell, Oliver
Berman, Albert
Coates, Ute
Reiser, Maximilian F.
Riedel, Michael
Möller, Hans-Jürgen
Ettinger, Ulrich
Meindl, Thomas
2014
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Mueller, Sophia
Costa, Anna
Keeser, Daniel
Pogarell, Oliver
Berman, Albert
Coates, Ute
Reiser, Maximilian F.
Riedel, Michael
Möller, Hans-Jürgen
Ettinger, Ulrich
Meindl, Thomas
Titel
The effects of methylphenidate on whole brain intrinsic functional connectivity
Ist Teil von
Human brain mapping, 2014-11, Vol.35 (11), p.5379-5388
Ort / Verlag
New York, NY: Blackwell Publishing Ltd
Erscheinungsjahr
2014
Quelle
Wiley-Blackwell Journals
Beschreibungen/Notizen
Methylphenidate (MPH) is an indirect dopaminergic and noradrenergic agonist that is used to treat attention deficit hyperactivity disorder and that has shown therapeutic potential in neuropsychiatric diseases such as depression, dementia, and Parkinson's disease. While effects of MPH on task‐induced brain activation have been investigated, little is known about how MPH influences the resting brain. To investigate the effects of 40 mg of oral MPH on intrinsic functional connectivity, we used resting state fMRI in 54 healthy male subjects in a double‐blind, randomized, placebo‐controlled study. Functional connectivity analysis employing ICA revealed seven resting state networks (RSN) of interest. Connectivity strength between the dorsal attention network and the thalamus was increased after MPH intake. Other RSN located in association cortex areas, such as the left and right frontoparietal networks and the executive control network, showed MPH‐induced connectivity increase to sensory‐motor and visual cortex regions and connectivity decrease to cortical and subcortical components of cortico‐striato‐thalamo‐cortical circuits (CST). RSN located in sensory‐motor cortex areas showed the opposite pattern with MPH‐induced connectivity increase to CST components and connectivity decrease to sensory‐motor and visual cortex regions. Our results provide evidence that MPH does not only alter intrinsic connectivity between brain areas involved in sustained attention, but that it also induces significant changes in the cortico‐cortical and cortico‐subcortical connectivity of many other cognitive and sensory‐motor RSN. Hum Brain Mapp 35:5379–5388, 2014. © 2014 Wiley Periodicals, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 1065-9471
eISSN: 1097-0193
DOI: 10.1002/hbm.22557
Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6869774
Format
–
Schlagworte
ADHD
,
Adult
,
Biological and medical sciences
,
Brain - drug effects
,
Brain - physiology
,
Central Nervous System Stimulants - pharmacology
,
dopamine agonist
,
Double-Blind Method
,
Electrodiagnosis. Electric activity recording
,
Humans
,
intrinsic functional connectivity
,
Investigative techniques, diagnostic techniques (general aspects)
,
Male
,
Medical sciences
,
methylphenidate
,
Methylphenidate - pharmacology
,
Models, Neurological
,
Nervous system
,
Neural Pathways - drug effects
,
Neural Pathways - physiology
,
Radiodiagnosis. Nmr imagery. Nmr spectrometry
,
Rest
,
resting state fMRI
,
Young Adult
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