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Increased cortical thickness in a frontoparietal network in social anxiety disorder
Human brain mapping, 2014-07, Vol.35 (7), p.2966-2977
Brühl, Annette Beatrix
Hänggi, Jürgen
Baur, Volker
Rufer, Michael
Delsignore, Aba
Weidt, Steffi
Jäncke, Lutz
Herwig, Uwe
2014
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Brühl, Annette Beatrix
Hänggi, Jürgen
Baur, Volker
Rufer, Michael
Delsignore, Aba
Weidt, Steffi
Jäncke, Lutz
Herwig, Uwe
Titel
Increased cortical thickness in a frontoparietal network in social anxiety disorder
Ist Teil von
Human brain mapping, 2014-07, Vol.35 (7), p.2966-2977
Ort / Verlag
New York, NY: Blackwell Publishing Ltd
Erscheinungsjahr
2014
Quelle
MEDLINE
Beschreibungen/Notizen
Social anxiety disorder (SAD) is the second leading anxiety disorder. On the functional neurobiological level, specific brain regions involved in the processing of anxiety‐laden stimuli and in emotion regulation have been shown to be hyperactive and hyper‐responsive in SAD such as amygdala, insula and orbito‐ and prefrontal cortex. On the level of brain structure, prior studies on anatomical differences in SAD resulted in mixed and partially contradictory findings. Based on previous functional and anatomical models of SAD, this study examined cortical thickness in structural magnetic resonance imaging data of 46 patients with SAD without comorbidities (except for depressed episode in one patient) compared with 46 matched healthy controls in a region of interest‐analysis and in whole‐brain. In a theory‐driven ROI‐analysis, cortical thickness was increased in SAD in left insula, right anterior cingulate and right temporal pole. Furthermore, the whole‐brain analysis revealed increased thickness in right dorsolateral prefrontal and right parietal cortex. This study detected no regions of decreased cortical thickness or brain volume in SAD. From the perspective of brain networks, these findings are in line with prior functional differences in salience networks and frontoparietal networks associated with executive‐controlling and attentional functions. Hum Brain Mapp 35:2966–2977, 2014. © 2013 Wiley Periodicals, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 1065-9471
eISSN: 1097-0193
DOI: 10.1002/hbm.22378
Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6869416
Format
–
Schlagworte
Adolescent
,
Adult
,
amygdale
,
Analysis of Variance
,
anatomy
,
anterior cingulate
,
anxiety disorders
,
Biological and medical sciences
,
Brain Mapping
,
DLPFC
,
dorsal attention network
,
emotion processing
,
Female
,
Frontal Lobe - pathology
,
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
,
hippocampus
,
Humans
,
Image Processing, Computer-Assisted
,
insula
,
Investigative techniques, diagnostic techniques (general aspects)
,
Magnetic Resonance Imaging
,
Male
,
Medical sciences
,
Middle Aged
,
MRI
,
Nerve Net - pathology
,
Nervous system
,
Nervous system (semeiology, syndromes)
,
Neurology
,
Parietal Lobe - pathology
,
Phobic Disorders - pathology
,
Radiodiagnosis. Nmr imagery. Nmr spectrometry
,
Young Adult
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