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Reproducibility of R‐fMRI metrics on the impact of different strategies for multiple comparison correction and sample sizes
Human brain mapping, 2018-01, Vol.39 (1), p.300-318
Chen, Xiao
Lu, Bin
Yan, Chao‐Gan
2018
Details
Autor(en) / Beteiligte
Chen, Xiao
Lu, Bin
Yan, Chao‐Gan
Titel
Reproducibility of R‐fMRI metrics on the impact of different strategies for multiple comparison correction and sample sizes
Ist Teil von
Human brain mapping, 2018-01, Vol.39 (1), p.300-318
Ort / Verlag
United States: John Wiley & Sons, Inc
Erscheinungsjahr
2018
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
Concerns regarding reproducibility of resting‐state functional magnetic resonance imaging (R‐fMRI) findings have been raised. Little is known about how to operationally define R‐fMRI reproducibility and to what extent it is affected by multiple comparison correction strategies and sample size. We comprehensively assessed two aspects of reproducibility, test–retest reliability and replicability, on widely used R‐fMRI metrics in both between‐subject contrasts of sex differences and within‐subject comparisons of eyes‐open and eyes‐closed (EOEC) conditions. We noted permutation test with Threshold‐Free Cluster Enhancement (TFCE), a strict multiple comparison correction strategy, reached the best balance between family‐wise error rate (under 5%) and test–retest reliability/replicability (e.g., 0.68 for test–retest reliability and 0.25 for replicability of amplitude of low‐frequency fluctuations (ALFF) for between‐subject sex differences, 0.49 for replicability of ALFF for within‐subject EOEC differences). Although R‐fMRI indices attained moderate reliabilities, they replicated poorly in distinct datasets (replicability < 0.3 for between‐subject sex differences, < 0.5 for within‐subject EOEC differences). By randomly drawing different sample sizes from a single site, we found reliability, sensitivity and positive predictive value (PPV) rose as sample size increased. Small sample sizes (e.g., < 80 [40 per group]) not only minimized power (sensitivity < 2%), but also decreased the likelihood that significant results reflect “true” effects (PPV < 0.26) in sex differences. Our findings have implications for how to select multiple comparison correction strategies and highlight the importance of sufficiently large sample sizes in R‐fMRI studies to enhance reproducibility. Hum Brain Mapp 39:300–318, 2018. © 2017 Wiley Periodicals, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 1065-9471
eISSN: 1097-0193
DOI: 10.1002/hbm.23843
Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6866539
Format
–
Schlagworte
Brain
,
Brain - diagnostic imaging
,
Brain - physiology
,
Brain mapping
,
Brain Mapping - methods
,
Error correction
,
Female
,
Functional magnetic resonance imaging
,
Gender aspects
,
Gender differences
,
Humans
,
Magnetic resonance imaging
,
Magnetic Resonance Imaging - methods
,
Male
,
multiple comparison correction strategies
,
Neuroimaging
,
Permutations
,
positive predictive value
,
Reliability analysis
,
Reliability aspects
,
replicability
,
Reproducibility
,
Reproducibility of Results
,
Rest
,
resting‐state fMRI
,
Sample Size
,
Sensitivity
,
Sex
,
Sex Characteristics
,
Sex differences
,
test–retest reliability
,
Visual Perception
,
Young Adult
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