Details

Autor(en) / Beteiligte

• Brix, Nis
• Ernst, Andreas
• Lauridsen, Lea L B
• Arah, Onyebuchi A
• Nohr, Ellen A
• Olsen, Jørn
• Henriksen, Tine Brink
• Ramlau-Hansen, Cecilia Høst

Titel

Maternal pre-pregnancy obesity and timing of puberty in sons and daughters: a population-based cohort study

Ist Teil von

• International journal of epidemiology, 2019-10, Vol.48 (5), p.1684-1694

Ort / Verlag

England: Oxford University Press

Erscheinungsjahr

2019

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Abstract Background In many countries, an increased prevalence of obesity in pregnancy has coincided with a declining pubertal age. We aimed to explore the potential effect of maternal pre-pregnancy overweight and obesity on timing of puberty in sons and daughters. Methods Between 2012 and 2018, 15 819 of 22 439 invited children from the Danish National Birth Cohort, born 2000–03, provided half-yearly information from the age of 11 years on the pubertal milestones: Tanner stages, voice break, first ejaculation, menarche, acne and axillary hair. We estimated adjusted mean monthly differences (with 95% confidence intervals) in age at attaining the pubertal milestones for children exposed to maternal pre-pregnancy obesity [body mass index (BMI) ≥30.0 kg/m2] or overweight (BMI 25.0 to 29.9 kg/m2) with normal weight (BMI 18.5 to 24.9 kg/m2) as reference. In mediation analysis, we explored whether childhood BMI at age 7 years mediated the associations. Results Maternal pre-pregnancy obesity was associated with earlier age at attaining most pubertal milestones in sons, and pre-pregnancy overweight and obesity were associated with earlier age at attaining all pubertal milestones in daughters. When combining all pubertal milestones, pre-pregnancy obesity [sons: −1.5 (−2.5, −0.4) months; daughters: −3.2 (−4.2, −2.1) months] and overweight [daughters only: −2.6 (−3.3, −1.8) months] were associated with earlier timing of puberty. The associations in sons were completely mediated by higher childhood BMI and partly so in daughters. Conclusions Maternal pre-pregnancy obesity appears to lower timing of puberty through childhood obesity in sons and mainly through other mechanisms in daughters.