Details

Autor(en) / Beteiligte

• Solomon, Anthony W
• Holland, Martin J
• Alexander, Neal D.E
• Massae, Patrick A
• Aguirre, Aura
• Natividad-Sancho, Angels
• Molina, Sandra
• Safari, Salesia
• Shao, John F
• Courtright, Paul
• Peeling, Rosanna W
• West, Sheila K
• Bailey, Robin L
• Foster, Allen
• Mabey, David C.W

Titel

Mass Treatment with Single-Dose Azithromycin for Trachoma

Ist Teil von

• The New England journal of medicine, 2004-11, Vol.351 (19), p.1962-1971

Ort / Verlag

Boston, MA: Massachusetts Medical Society

Erscheinungsjahr

2004

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Trachoma, an important cause of blindness, is caused by infection with Chlamydia trachomatis . In a Tanzanian community in which trachoma was endemic, the residents each received a single dose of azithromycin. After 24 months, the infection had virtually been eradicated from the community. In a Tanzanian community in which trachoma was endemic, Chlamydia trachomatis was virtually eradicated. Trachoma is a chronic keratoconjunctivitis caused by the bacterium Chlamydia trachomatis . Resolution of ocular chlamydial infections may be accompanied by scarring of the conjunctivae. Over many years, contraction of upper-lid scars produced during multiple episodes of infection 1 causes the eyelashes of some patients to deviate inward so that they abrade the globe. This complication, termed “trichiasis,” leads to scarring of the cornea. Trachoma is the most common infectious cause of blindness. 2 Until the 1990s, attempts to control trachoma with antibiotics yielded mostly disappointing results. Mass administration of oral sulfonamides in North America in the 1930s and 1940s was associated . . .