Details

Autor(en) / Beteiligte

• Sanders, Travis J.
• Marshall, Craig J.
• Santangelo, Thomas J.

Titel

The Role of Archaeal Chromatin in Transcription

Ist Teil von

• Journal of molecular biology, 2019-09, Vol.431 (20), p.4103-4115

Ort / Verlag

Netherlands: Elsevier Ltd

Erscheinungsjahr

2019

Quelle

MEDLINE

Beschreibungen/Notizen

• Genomic organization impacts accessibility and movement of information processing systems along DNA. DNA-bound proteins dynamically dictate gene expression and provide regulatory potential to tune transcription rates to match ever-changing environmental conditions. Archaeal genomes are typically small, circular, gene dense, and organized either by histone proteins that are homologous to their eukaryotic counterparts, or small basic proteins that function analogously to bacterial nucleoid proteins. We review here how archaeal genomes are organized and how such organization impacts archaeal gene expression, focusing on conserved DNA-binding proteins within the clade and the factors that are known to impact transcription initiation and elongation within protein-bound genomes. [Display omitted] •Archaea encode histone proteins and nucleoid-associated proteins to organize DNA.•Archaeal and eukaryotic histones wrap DNA in a similar geometry.•Extended histone-based chromatin structures regulate archaeal gene expression.•Conserved transcription factors facilitate transcription through archaeal chromatin.•Unique archaeal histone isoforms may provide regulatory potential.•Nucleoid-associated proteins (NAPs) are diverse, especially in the Crenarchaeota.•Archaeal NAPs likely bind and influence both RNA and DNA structure and dynamics.•Post-translational modification control of NAP activity is heavily debated.