Details

Autor(en) / Beteiligte

• Liesche, Friederike
• Ruf, Viktoria
• Zoubaa, Saida
• Kaletka, Gwendolyn
• Rosati, Marco
• Rubbenstroth, Dennis
• Herden, Christiane
• Goehring, Lutz
• Wunderlich, Silke
• Wachter, Miguel Frederic
• Rieder, Georg
• Lichtmannegger, Ines
• Permanetter, Willibald
• Heckmann, Josef G.
• Angstwurm, Klemens
• Neumann, Bernhard
• Märkl, Bruno
• Haschka, Stefan
• Niller, Hans-Helmut
• Schmidt, Barbara
• Jantsch, Jonathan
• Brochhausen, Christoph
• Schlottau, Kore
• Ebinger, Arnt
• Hemmer, Bernhard
• Riemenschneider, Markus J.
• Herms, Jochen
• Beer, Martin
• Matiasek, Kaspar
• Schlegel, Jürgen

Titel

The neuropathology of fatal encephalomyelitis in human Borna virus infection

Ist Teil von

• Acta neuropathologica, 2019-10, Vol.138 (4), p.653-665

Ort / Verlag

Berlin/Heidelberg: Springer Berlin Heidelberg

Erscheinungsjahr

2019

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• After many years of controversy, there is now recent and solid evidence that classical Borna disease virus 1 (BoDV-1) can infect humans. On the basis of six brain autopsies, we provide the first systematic overview on BoDV-1 tissue distribution and the lesion pattern in fatal BoDV-1-induced encephalitis. All brains revealed a non-purulent, lymphocytic sclerosing panencephalomyelitis with detection of BoDV-1-typical eosinophilic, spherical intranuclear Joest–Degen inclusion bodies. While the composition of histopathological changes was constant, the inflammatory distribution pattern varied interindividually, affecting predominantly the basal nuclei in two patients, hippocampus in one patient, whereas two patients showed a more diffuse distribution. By immunohistochemistry and RNA in situ hybridization, BoDV-1 was detected in all examined brain tissue samples. Furthermore, infection of the peripheral nervous system was observed. This study aims at raising awareness to human bornavirus encephalitis as differential diagnosis in lymphocytic sclerosing panencephalomyelitis. A higher attention to human BoDV-1 infection by health professionals may likely increase the detection of more cases and foster a clearer picture of the disease.