The Journal of neuroscience, 2001-08, Vol.21 (16), p.6423-6429
2001
Details
- Autor(en) / Beteiligte
- Titel
- Alleviation of a Selective Age-Related Relational Memory Deficit in Mice by Pharmacologically Induced Normalization of Brain Retinoid Signaling
- Ist Teil von
- The Journal of neuroscience, 2001-08, Vol.21 (16), p.6423-6429
- Ort / Verlag
- United States: Soc Neuroscience
- Erscheinungsjahr
- 2001
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Vitamin A and its derivatives, the retinoids, have been implicated recently in the synaptic plasticity of the hippocampus and might therefore play a role in associated cognitive functions. Acting via transcription factors, retinoids can regulate gene expression via their nuclear receptors [retinoic acid receptors (RARs) and retinoid X receptors]. In a series of experiments, the present study investigated the possible role of age-related downregulation of retinoid-mediated transcription events in the cognitive decline seen in aged mice. We observed that the brain (and hippocampal) levels of retinoid receptors and the expression of specific associated target genes were restored to presenescent (adult) levels in aged mice after acute administration (150 microg/kg, s.c.) of retinoic acid (RA). These effects of RA, however, could be abolished by the coadministration of an RAR antagonist. RA was also demonstrated to alleviate the age-related deficit in the CA1 long-term potentiation efficacy of aged mice in vivo. Moreover, RA was found to alleviate completely the performance deficit of aged mice to the control level in a two-stage spatial discrimination paradigm designed to assess relational memory. This promnesic effect of RA was again susceptible to abolition by RAR antagonist treatment. The parallel molecular, cellular, and behavioral correlates associated with the decrease of retinoid receptor expression and its normalization demonstrated here suggest that the fine regulation of retinoid-mediated gene expression is fundamentally important to optimal brain functioning and higher cognition. Specifically, a naturally occurring dysregulation of retinoid-mediated molecular events might be a potential etiological factor for cognitive deterioration during senescence.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0270-6474eISSN: 1529-2401DOI: 10.1523/jneurosci.21-16-06423.2001Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6763177
- Format
- –
- Schlagworte
- Aging, Aging - metabolism, Animals, Behavior, Animal, Behavior, Animal - drug effects, Brain, Brain - drug effects, Brain - physiopathology, Brain Chemistry, Brain Chemistry - drug effects, Calmodulin-Binding Proteins, Calmodulin-Binding Proteins - metabolism, Cognitive Sciences, Down-Regulation, Down-Regulation - drug effects, Electric Stimulation, Hippocampus, Hippocampus - chemistry, Hippocampus - drug effects, Hippocampus - physiopathology, Injections, Subcutaneous, Life Sciences, Long-Term Potentiation, Long-Term Potentiation - drug effects, Male, Memory, Memory - drug effects, Memory Disorders, Memory Disorders - drug therapy, Memory Disorders - physiopathology, Mice, Mice, Inbred C57BL, Nerve Tissue Proteins, Nerve Tissue Proteins - metabolism, Neurobiology, Neurogranin, Neurons and Cognition, Psychology and behavior, Receptors, Retinoic Acid, Receptors, Retinoic Acid - antagonists & inhibitors, Receptors, Retinoic Acid - genetics, Receptors, Retinoic Acid - metabolism, Retinoid X Receptors, Retinoids, Retinoids - metabolism, RNA, Messenger, RNA, Messenger - analysis, RNA, Messenger - metabolism, Signal Transduction, Signal Transduction - drug effects, Transcription Factors, Transcription Factors - genetics, Transcription Factors - metabolism, Tretinoin, Tretinoin - administration & dosage