The Journal of neuroscience, 2001-09, Vol.21 (18), p.7161-7170
2001
Details
- Autor(en) / Beteiligte
- Titel
- Leukemia Inhibitory Factor Determines the Growth Status of Injured Adult Sensory Neurons
- Ist Teil von
- The Journal of neuroscience, 2001-09, Vol.21 (18), p.7161-7170
- Ort / Verlag
- United States: Soc Neuroscience
- Erscheinungsjahr
- 2001
- Link zum Volltext
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- Conditioning injury to adult mammalian sensory neurons enhances their regeneration potential. Here we show that leukemia inhibitory factor (LIF) is a fundamental component of the conditioning response. Conditioning injury in vivo significantly increases the intrinsic growth capacity of sensory neurons in vitro from LIF+/+ mice. This conditioning effect is significantly blunted in sensory neurons from LIF-/- mice. Enhanced growth is rescued in vitro in LIF-/- mice by the addition of exogenous LIF, and the effect blocked by human LIF-05, an LIF receptor antagonist. Furthermore, we demonstrate that LIF promotes elongating but not arborizing neurite outgrowth in vitro and is required for normal regeneration of injured adult sensory neurons in vivo. LIF is also functionally protective to peptidergic sensory neurons after nerve damage in vivo. Our results indicate that the alteration in intrinsic growth status of injured sensory neurons depends, at least in part, on LIF.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0270-6474eISSN: 1529-2401DOI: 10.1523/jneurosci.21-18-07161.2001Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6762988
- Format
- –
- Schlagworte
- Animals, Axotomy, Calcitonin Gene-Related Peptide - biosynthesis, Cell Division - drug effects, Cell Division - physiology, Cell Survival - drug effects, Cells, Cultured, Cytoprotection - drug effects, Female, Ganglia, Spinal - cytology, Ganglia, Spinal - drug effects, Growth Inhibitors - administration & dosage, Growth Inhibitors - genetics, Growth Inhibitors - metabolism, Injections, Spinal, Interleukin-6, Leukemia Inhibitory Factor, Lymphokines - administration & dosage, Lymphokines - genetics, Lymphokines - metabolism, Male, Mice, Mice, Knockout, Nerve Fibers - metabolism, Nerve Regeneration - drug effects, Nerve Regeneration - physiology, Neurites - drug effects, Neurites - physiology, Neurons, Afferent - cytology, Neurons, Afferent - drug effects, Neurons, Afferent - metabolism, Phenotype, Rats, Rats, Wistar, Sciatic Nerve - physiology, Tibial Nerve - physiology