British journal of cancer, 2019-08, Vol.121 (5), p.405-416
2019
Details
- Autor(en) / Beteiligte
- Titel
- Distinct prognostic value of circulating anti-telomerase CD4 + Th1 immunity and exhausted PD-1 + /TIM-3 + T cells in lung cancer
- Ist Teil von
- British journal of cancer, 2019-08, Vol.121 (5), p.405-416
- Ort / Verlag
- England: Nature Publishing Group
- Erscheinungsjahr
- 2019
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Despite the critical roles of Th1-polarised CD4 T cells in cancer immunosurveillance, the translation of their potential to clinical use remains challenging. Here, we investigate the clinical relevance of circulating antitumor Th1 immunity in non-small cell lung cancer (NSCLC). The circulating antitumor Th1 response was assessed by the ELISpot assay in 170 NSCLC patients using a mixture of HLA class II-restricted peptides from telomerase (TERT). Phenotyping of blood immune cells was performed by flow cytometry. TERT-reactive CD4 T-cell response was detected in 35% of NSCLC patients before any treatment. Functional analysis showed that these cells were effector memory and Th1 polarised capable to produce effector cytokines, such as IFN-γ, TNF-α and IL-2. The presence of anti-TERT Th1 response was inversely correlated with the level of exhausted PD-1 /TIM-3 CD4 T cells. The level of these two immune parameters differentially affected the survival, so that increased level of anti-TERT Th1 response and low rate of exhausted PD-1 TIM-3 CD4 T cells were associated with a better prognosis. Systemic anti-TERT Th1 response plays a strong antitumor protective role in NSCLC. This study underlines the potential interest of monitoring circulating antitumor Th1 response for patients' stratification and therapy decision.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0007-0920eISSN: 1532-1827DOI: 10.1038/s41416-019-0531-5Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6738094
- Format
- –
- Schlagworte
- Adaptive immunology, Aged, Antitumor activity, Cancer, Carcinoma, Non-Small-Cell Lung - immunology, CD4 antigen, Cytokines, Cytokines - immunology, Effector cells, Enzyme-linked immunosorbent assay, Female, Flow cytometry, Functional analysis, Hepatitis A Virus Cellular Receptor 2 - immunology, Histocompatibility antigen HLA, Human health and pathology, Humans, Immunity, Immunological memory, Immunology, Immunosurveillance, In Vitro Techniques, Interleukin 2, Life Sciences, Lung cancer, Lung Neoplasms - immunology, Lymphocytes, Lymphocytes T, Male, Medical prognosis, Middle Aged, Non-small cell lung carcinoma, Patients, PD-1 protein, Peptides, Phenotyping, Prognosis, Programmed Cell Death 1 Receptor - immunology, Pulmonology and respiratory tract, Survival Rate, T-Lymphocyte Subsets - immunology, T-Lymphocytes - immunology, Telomerase, Telomerase - immunology, Th1 Cells - immunology, Tumor necrosis factor-α, γ-Interferon