Details

Autor(en) / Beteiligte

• Acuña-Villaorduña, Carlos
• Jones-López, Edward C
• Fregona, Geisa
• Marques-Rodrigues, Patricia
• Gaeddert, Mary
• Geadas, Carolina
• Hadad, David Jamil
• White, Laura F
• Pereira Dutra Molina, Lucilia
• Vinhas, Solange
• Ribeiro-Rodrigues, Rodrigo
• Salgame, Padmini
• Palaci, Moises
• Alland, David
• Ellner, Jerrold J
• Dietze, Reynaldo

Titel

Intensity of exposure to pulmonary tuberculosis determines risk of tuberculosis infection and disease

Ist Teil von

• The European respiratory journal, 2018-01, Vol.51 (1), p.1701578-1701578

Ort / Verlag

England: European Respiratory Society Journals Ltd

Erscheinungsjahr

2018

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Household contacts of pulmonary tuberculosis (TB) patients are at increased risk of TB infection and disease. However, their risk in relation to the intensity of exposure remains unknown.We studied smear-positive TB cases and their household contacts in Vitória, Brazil. We collected clinical, demographic and radiographic information from TB cases, and obtained tuberculin skin test (TST) and QuantiFERON-TB Gold (QFT) results from household contacts. We measured intensity of exposure using a proximity score and sleep location in relation to the TB index case and defined infection by TST ≥10 mm or QFT ≥0.35 UI·mL We ascertained secondary TB cases by reviewing local and nationwide case registries.We included 160 TB index cases and 894 household contacts. 464 (65%) had TB infection and 23 (2.6%) developed TB disease. Risk of TB infection and disease increased with more intense exposures. In an adjusted analysis, the proximity score was associated with TB disease (OR 1.61, 95% CI 1.25-2.08; p<0.000); however, its diagnostic performance was only moderate.Intensity of exposure increased risk of TB infection and disease among household contacts; however, its diagnostic performance was still suboptimal. A biomarker to target preventive therapy is urgently needed in this at-risk population.