Details

Autor(en) / Beteiligte

• Fenske, Gavin J
• Thachil, Anil
• McDonough, Patrick L
• Glaser, Amy
• Scaria, Joy
• Delaye, Luis

Titel

Geography Shapes the Population Genomics of Salmonella enterica Dublin

Ist Teil von

• Genome biology and evolution, 2019-08, Vol.11 (8), p.2220-2231

Ort / Verlag

England: Oxford University Press

Erscheinungsjahr

2019

Quelle

MEDLINE

Beschreibungen/Notizen

• Abstract Salmonella enterica serotype Dublin (S. Dublin) is a bovine-adapted serotype that can cause serious systemic infections in humans. Despite the increasing prevalence of human infections and the negative impact on agricultural processes, little is known about the population structure of the serotype. To this end, we compiled a manually curated data set comprising of 880 S. Dublin genomes. Core genome phylogeny and ancestral state reconstruction revealed that region-specific clades dominate the global population structure of S. Dublin. Strains of S. Dublin in the UK are genomically distinct from US, Brazilian, and African strains. The geographical partitioning impacts the composition of the core genome as well as the ancillary genome. Antibiotic resistance genes are almost exclusively found in US genomes and are mediated by an IncA/C2 plasmid. Phage content and the S. Dublin virulence plasmid were strongly conserved in the serotype. Comparison of S. Dublin to a closely related serotype, S. enterica serotype Enteritidis, revealed that S. Dublin contains 82 serotype specific genes that are not found in S. Enteritidis. Said genes encode metabolic functions involved in the uptake and catabolism of carbohydrates and virulence genes associated with type VI secretion systems and fimbria assembly respectively.