Details

Autor(en) / Beteiligte

• Sardini, Stephen R
• Lambright, Alison L
• Trammel, Grace L
• Omer, Humair M
• Liu, Peng
• Brown, M. Kevin

Titel

Ni-Catalyzed Arylboration of Unactivated Alkenes: Scope and Mechanistic Studies

Ist Teil von

• Journal of the American Chemical Society, 2019-06, Vol.141 (23), p.9391-9400

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2019

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A method for the Ni-catalyzed arylboration of unactivated monosubstituted, 1,1-disubstituted, and trisubstituted alkenes is disclosed. The reaction is notable in that it converts highly substituted alkenes, aryl bromides, and diboron reagents to products that contain a quaternary carbon and a synthetically versatile carbon–boron bond with control of stereoselectivity and regioselectivity. In addition, the method is demonstrated to be useful for the synthesis of saturated nitrogen heterocycles, which are important motifs in pharmaceutical compounds. Finally, due to the unusual reactivity demonstrated, the mechanistic details of the reaction were studied with both computational and experimental techniques.