Science (American Association for the Advancement of Science), 2019-03, Vol.363 (6434)
- Sweere, Johanna M
- Van Belleghem, Jonas D
- Ishak, Heather
- Bach, Michelle S
- Popescu, Medeea
- Sunkari, Vivekananda
- Kaber, Gernot
- Manasherob, Robert
- Suh, Gina A
- Cao, Xiou
- de Vries, Christiaan R
- Lam, Dung N
- Marshall, Payton L
- Birukova, Maria
- Katznelson, Ethan
- Lazzareschi, Daniel V
- Balaji, Swathi
- Keswani, Sundeep G
- Hawn, Thomas R
- Secor, Patrick R
- Bollyky, Paul L
2019
Details
- Autor(en) / Beteiligte
- Sweere, Johanna M
- Van Belleghem, Jonas D
- Ishak, Heather
- Bach, Michelle S
- Popescu, Medeea
- Sunkari, Vivekananda
- Kaber, Gernot
- Manasherob, Robert
- Suh, Gina A
- Cao, Xiou
- de Vries, Christiaan R
- Lam, Dung N
- Marshall, Payton L
- Birukova, Maria
- Katznelson, Ethan
- Lazzareschi, Daniel V
- Balaji, Swathi
- Keswani, Sundeep G
- Hawn, Thomas R
- Secor, Patrick R
- Bollyky, Paul L
- Titel
- Bacteriophage trigger antiviral immunity and prevent clearance of bacterial infection
- Ist Teil von
- Science (American Association for the Advancement of Science), 2019-03, Vol.363 (6434)
- Ort / Verlag
- United States: The American Association for the Advancement of Science
- Erscheinungsjahr
- 2019
- Link zum Volltext
- Quelle
- American Association for the Advancement of Science
- Beschreibungen/Notizen
- Bacteriophage are abundant at sites of bacterial infection, but their effects on mammalian hosts are unclear. We have identified pathogenic roles for filamentous Pf bacteriophage produced by ( ) in suppression of immunity against bacterial infection. Pf promote wound infection in mice and are associated with chronic human wound infections. Murine and human leukocytes endocytose Pf, and internalization of this single-stranded DNA virus results in phage RNA production. This triggers Toll-like receptor 3 (TLR3)- and TIR domain-containing adapter-inducing interferon-β (TRIF)-dependent type I interferon production, inhibition of tumor necrosis factor (TNF), and the suppression of phagocytosis. Conversely, immunization of mice against Pf prevents wound infection. Thus, Pf triggers maladaptive innate viral pattern-recognition responses, which impair bacterial clearance. Vaccination against phage virions represents a potential strategy to prevent bacterial infection.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0036-8075eISSN: 1095-9203DOI: 10.1126/science.aat9691Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6656896
- Format
- –
- Schlagworte
- Adapters, Adaptor Proteins, Vesicular Transport - genetics, Adaptor Proteins, Vesicular Transport - immunology, Animal models, Animals, Antibiotic resistance, Antibiotics, Antibodies, Viral - immunology, Attrition (Research Studies), Bacteria, Bacterial infections, Chronic infection, Cystic fibrosis, Deoxyribonucleic acid, DNA, E coli, Endocytosis, Gram-negative bacteria, Health care, Humans, Immune clearance, Immune response, Immune system, Immune Tolerance, Immunity, Immunization, Immunization (passive), Infections, Inhibition, Interferon, Interferons - immunology, Internalization, Klebsiella, Leukocytes, Lungs, Male, Mammals, Mice, Mice, Inbred C57BL, Mice, Mutant Strains, Monoclonal antibodies, Morbidity, Mortality, mRNA, Multidrug resistance, Pathogenesis, Pathogens, Pathophysiology, Pattern recognition, Phages, Phagocytosis, Phagocytosis - immunology, Proteins, Pseudomonas aeruginosa, Pseudomonas aeruginosa - pathogenicity, Pseudomonas aeruginosa - virology, Pseudomonas Infections - immunology, Pseudomonas Phages - immunology, Pseudomonas Phages - physiology, Ribonucleic acid, RNA, Toll-Like Receptor 3 - genetics, Toll-Like Receptor 3 - immunology, Toll-like receptors, Tumor Necrosis Factor-alpha - metabolism, Tumor necrosis factor-TNF, Tumors, Vaccination, Vaccines, Virions, Virulence, Viruses, Waterborne diseases, Wound infection, Wound Infection - immunology, β-Interferon