Details

Autor(en) / Beteiligte

• Moreno, Amy C.
• Frank, Steven J.
• Garden, Adam S.
• Rosenthal, David I.
• Fuller, Clifton D.
• Gunn, Gary B.
• Reddy, Jay P
• Morrison, William H.
• Williamson, Tyler D.
• Holliday, Emma B.
• Phan, Jack
• Blanchard, Pierre

Titel

Intensity modulated proton therapy (IMPT) – The future of IMRT for head and neck cancer

Ist Teil von

• Oral oncology, 2019-01, Vol.88, p.66-74

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2019

Quelle

MEDLINE

Beschreibungen/Notizen

• •Intensity modulated proton therapy (IMPT) is a sophisticated mode of proton therapy.•Dosimetric studies have demonstrated the superiority of IMPT over IMRT to improve dose sparing of organs in located in the head and neck.•There is clinical evidence that IMPT can translate to toxicity reductions for patients with HNCs.•This review will discuss existing literature and future directions of IMPT use for HNCs. Radiation therapy plays an integral role in the management of head and neck cancers (HNCs). While most HNC patients have historically been treated with photon-based radiation techniques such as intensity modulated radiation therapy (IMRT), there is a growing awareness of the potential clinical benefits of proton therapy over IMRT in the definitive, postoperative and reirradiation settings given the unique physical properties of protons. Intensity modulated proton therapy (IMPT), also known as “pencil beam proton therapy,” is a sophisticated mode of proton therapy that is analogous to IMRT and an active area of investigation in cancer care. Multifield optimization IMPT allows for high quality plans that can target superficially located HNCs as well as large neck volumes while significantly reducing integral doses. Several dosimetric studies have demonstrated the superiority of IMPT over IMRT to improve dose sparing of nearby organs such as the larynx, salivary glands, and esophagus. Evidence of the clinical translation of these dosimetric advantages has been demonstrated with documented toxicity reductions (such as decreased feeding tube dependency) after IMPT for patients with HNCs. While there are relative challenges to IMPT planning that exist today such as particle range uncertainties and high sensitivity to anatomical changes, ongoing investigations in image-guidance techniques and robust optimization methods are promising. A systematic approach towards utilizing IMPT and additional prospective studies are necessary in order to more accurately estimate the clinical benefit of IMPT over IMRT and passive proton therapy on a case-by-case basis for patients with sub-site specific HNCs.