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Paternal and joint parental occupational pesticide exposure and spina bifida in the National Birth Defects Prevention Study, 1997 to 2002
Birth defects research. A Clinical and molecular teratology, 2016-11, Vol.106 (11), p.963-971
Pettigrew, Stacy M.
Bell, Erin M.
Van Zutphen, Alissa R.
Rocheleau, Carissa M.
Shaw, Gary M.
Romitti, Paul A.
Olshan, Andrew
Lupo, Philip J.
Soim, Aida
Makelarski, Jennifer A.
Michalski, Adrian M.
Sanderson, Wayne
2016
Details
Autor(en) / Beteiligte
Pettigrew, Stacy M.
Bell, Erin M.
Van Zutphen, Alissa R.
Rocheleau, Carissa M.
Shaw, Gary M.
Romitti, Paul A.
Olshan, Andrew
Lupo, Philip J.
Soim, Aida
Makelarski, Jennifer A.
Michalski, Adrian M.
Sanderson, Wayne
Titel
Paternal and joint parental occupational pesticide exposure and spina bifida in the National Birth Defects Prevention Study, 1997 to 2002
Ist Teil von
Birth defects research. A Clinical and molecular teratology, 2016-11, Vol.106 (11), p.963-971
Ort / Verlag
United States: Blackwell Publishing Ltd
Erscheinungsjahr
2016
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
Background Because of persistent concerns over the association between pesticides and spina bifida, we examined the role of paternal and combined parental occupational pesticide exposures in spina bifida in offspring using data from a large population‐based study of birth defects. Methods Occupational information from fathers of 291 spina bifida cases and 2745 unaffected live born control infants with estimated dates of delivery from 1997 to 2002 were collected by means of maternal report. Two expert industrial hygienists estimated exposure intensity and frequency to insecticides, herbicides, and fungicides. Multivariable logistic regression models were used to estimate adjusted odds ratios (aOR) and 95% confidence intervals (CI) for exposure to any pesticide and to any class of pesticide (yes/no; and by median), and exposure to combinations of pesticides (yes/no) and risk of spina bifida. Adjusted odds ratios were also estimated by parent exposed to pesticides (neither, mother only, father only, both parents). RESULTS Joint parental occupational pesticide exposure was positively associated with spina bifida (aOR, 1.5; 95% CI, 0.9–2.4) when compared with infants with neither maternal nor paternal exposures; a similar association was not observed when only one parent was exposed. There was a suggested positive association between combined paternal insecticide and fungicide exposures and spina bifida (aOR, 1.5; 95% CI, 0.8–2.8), however, nearly all other aORs were close to unity. Conclusion Overall, there was little evidence paternal occupational pesticide exposure was associated with spina bifida. However, the small numbers make it difficult to precisely evaluate the role of pesticide classes, individually and in combination. Birth Defects Research (Part A) 106:963–971, 2016. © 2016 Wiley Periodicals, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 1542-0752
eISSN: 1542-0760
DOI: 10.1002/bdra.23551
Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6613649
Format
–
Schlagworte
birth defects
,
Female
,
fungicides
,
herbicides
,
Humans
,
insecticides
,
Male
,
Maternal Exposure - adverse effects
,
neural tube defects
,
Occupational Exposure - adverse effects
,
occupational paternal and parental exposures
,
Paternal Exposure - adverse effects
,
pesticides
,
Pesticides - toxicity
,
Retrospective Studies
,
spina bifida
,
Spinal Dysraphism - chemically induced
,
Spinal Dysraphism - epidemiology
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