Scientific reports, 2019-06, Vol.9 (1), p.8711-13, Article 8711
2019
Details
- Autor(en) / Beteiligte
- Titel
- Rosmarinic acid suppresses Alzheimer's disease development by reducing amyloid β aggregation by increasing monoamine secretion
- Ist Teil von
- Scientific reports, 2019-06, Vol.9 (1), p.8711-13, Article 8711
- Ort / Verlag
- England: Nature Publishing Group
- Erscheinungsjahr
- 2019
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- A new mechanism is revealed by which a polyphenol, rosmarinic acid (RA), suppresses amyloid β (Aβ) accumulation in mice. Here we examined the brains of mice (Alzheimer's disease model) using DNA microarray analysis and revealed that the dopamine (DA)-signaling pathway was enhanced in the group fed RA versus controls. In the cerebral cortex, the levels of monoamines, such as norepinephrine, 3,4-dihydroxyphenylacetic acid, DA, and levodopa, increased after RA feeding. The expression of DA-degrading enzymes, such as monoamine oxidase B (Maob), was significantly downregulated in the substantia nigra and ventral tegmental area, both DA synthesis regions. Following in vitro studies showing that monoamines inhibited Aβ aggregation, this in vivo study, in which RA intake increased concentration of monoamine by reducing Maob gene expression, builds on that knowledge by demonstrating that monoamines suppress Aβ aggregation. In conclusion, RA-initiated monoamine increase in the brain may beneficially act against AD.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 2045-2322eISSN: 2045-2322DOI: 10.1038/s41598-019-45168-1Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6581955
- Format
- –
- Schlagworte
- Alzheimer Disease - genetics, Alzheimer Disease - metabolism, Alzheimer Disease - prevention & control, Alzheimer's disease, Amine oxidase (flavin-containing), Amyloid beta-Peptides - genetics, Amyloid beta-Peptides - metabolism, Animals, Antioxidants - pharmacology, Biogenic Monoamines - metabolism, Brain - drug effects, Brain - metabolism, Cerebral cortex, Cinnamates - pharmacology, Depsides - pharmacology, Dihydroxyphenylacetic acid, DNA microarrays, Dopamine, Female, Gene expression, Gene Expression Profiling - methods, Gene Ontology, Levodopa, Mice, Inbred C57BL, Mice, Transgenic, Monoamine Oxidase - genetics, Monoamine Oxidase - metabolism, Monoamines, Norepinephrine, Norepinephrine - metabolism, Oligonucleotide Array Sequence Analysis - methods, Protein Aggregation, Pathological - prevention & control, Rosmarinic Acid, Secretion, Signal transduction, Substantia nigra, Substantia Nigra - drug effects, Substantia Nigra - metabolism, Ventral Tegmental Area - drug effects, Ventral Tegmental Area - metabolism, Ventral tegmentum