Details

Autor(en) / Beteiligte

• Piccirillo, Ann R
• Hyzny, Eric J
• Beppu, Lisa Y
• Menk, Ashley V
• Wallace, Callen T
• Hawse, William F
• Buechel, Heather M
• Wong, Bernice H
• Foo, Juat Chin
• Cazenave-Gassiot, Amaury
• Wenk, Markus R
• Delgoffe, Greg M
• Watkins, Simon C
• Silver, David L
• D'Cruz, Louise M

Titel

The Lysophosphatidylcholine Transporter MFSD2A Is Essential for CD8 + Memory T Cell Maintenance and Secondary Response to Infection

Ist Teil von

• The Journal of immunology (1950), 2019-07, Vol.203 (1), p.117-126

Ort / Verlag

United States

Erscheinungsjahr

2019

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Access to nutrients is critical for an effective T cell immune response to infection. Although transporters for sugars and amino acids have previously been described in the context of the CD8 T cell immune response, the active transport of exogenous fatty acids has remained enigmatic. In this study, we discovered that the sodium-dependent lysophosphatidylcholine (LPC) transporter major facilitator superfamily domain containing 2A (MFSD2A) is upregulated on activated CD8 T cells and is required for memory T cell maintenance. MFSD2A deficiency in mice resulted in decreased import of LPC esterified to long chain fatty acids into activated CD8 T cells, and MFSD2A-deficient cells are at a competitive disadvantage resulting in reduced memory T cell formation and maintenance and reduced response to secondary infection. Mechanistically, import of LPCs was required to maintain T cell homeostatic turnover, which when lost resulted in a decreased memory T cell pool and thus a reduced secondary response to repeat infection.