Details

Autor(en) / Beteiligte

• Danese, Elisa
• Raimondi, Sara
• Montagnana, Martina
• Tagetti, Angela
• Langaee, Taimour
• Borgiani, Paola
• Ciccacci, Cinzia
• Carcas, Antonio J.
• Borobia, Alberto M.
• Tong, Hoi Y.
• Dávila‐Fajardo, Cristina
• Rodrigues Botton, Mariana
• Bourgeois, Stephane
• Deloukas, Panos
• Caldwell, Michael D.
• Burmester, Jim K.
• Berg, Richard L.
• Cavallari, Larisa H.
• Drozda, Katarzyna
• Huang, Min
• Zhao, Li‐Zi
• Cen, Han‐Jing
• Gonzalez‐Conejero, Rocio
• Roldan, Vanessa
• Nakamura, Yusuke
• Mushiroda, Taisei
• Gong, Inna Y.
• Kim, Richard B.
• Hirai, Keita
• Itoh, Kunihiko
• Isaza, Carlos
• Beltrán, Leonardo
• Jiménez‐Varo, Enrique
• Cañadas‐Garre, Marisa
• Giontella, Alice
• Kringen, Marianne K.
• Haug, Kari Bente Foss
• Gwak, Hye Sun
• Lee, Kyung Eun
• Minuz, Pietro
• Lee, Ming Ta Michael
• Lubitz, Steven A.
• Scott, Stuart
• Mazzaccara, Cristina
• Sacchetti, Lucia
• Genç, Ece
• Özer, Mahmut
• Pathare, Anil
• Krishnamoorthy, Rajagopal
• Paldi, Andras
• Siguret, Virginie
• Loriot, Marie‐Anne
• Kutala, Vijay Kumar
• Suarez‐Kurtz, Guilherme
• Perini, Jamila
• Denny, Josh C.
• Ramirez, Andrea H.
• Mittal, Balraj
• Rathore, Saurabh Singh
• Sagreiya, Hersh
• Altman, Russ
• Shahin, Mohamed Hossam A.
• Khalifa, Sherief I.
• Limdi, Nita A.
• Rivers, Charles
• Shendre, Aditi
• Dillon, Chrisly
• Suriapranata, Ivet M.
• Zhou, Hong‐Hao
• Tan, Sheng‐Lan
• Tatarunas, Vacis
• Lesauskaite, Vaiva
• Zhang, Yumao
• Maitland‐van der Zee, Anke H.
• Verhoef, Talitha I.
• Boer, Anthonius
• Taljaard, Monica
• Zambon, Carlo Federico
• Pengo, Vittorio
• Zhang, Jieying Eunice
• Pirmohamed, Munir
• Johnson, Julie A.
• Fava, Cristiano

Titel

Effect of CYP4F2, VKORC1, and CYP2C9 in Influencing Coumarin Dose: A Single‐Patient Data Meta‐Analysis in More Than 15,000 Individuals

Ist Teil von

• Clinical pharmacology and therapeutics, 2019-06, Vol.105 (6), p.1477-1491

Ort / Verlag

United States

Erscheinungsjahr

2019

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The cytochrome P450 (CYP)4F2 gene is known to influence mean coumarin dose. The aim of the present study was to undertake a meta‐analysis at the individual patients level to capture the possible effect of ethnicity, gene—gene interaction, or other drugs on the association and to verify if inclusion of CYP4F2*3 variant into dosing algorithms improves the prediction of mean coumarin dose. We asked the authors of our previous meta‐analysis (30 articles) and of 38 new articles retrieved by a systematic review to send us individual patients’ data. The final collection consists of 15,754 patients split into a derivation and validation cohort. The CYP4F2*3 polymorphism was consistently associated with an increase in mean coumarin dose (+9% (95% confidence interval (CI) 7–10%), with a higher effect in women, in patients taking acenocoumarol, and in white patients. The inclusion of the CYP4F2*3 in dosing algorithms slightly improved the prediction of stable coumarin dose. New pharmacogenetic equations potentially useful for clinical practice were derived.