Details

Autor(en) / Beteiligte

• McHugh, Kevin J.
• Nguyen, Thanh D.
• Linehan, Allison R.
• Yang, David
• Behrens, Adam M.
• Rose, Sviatlana
• Tochka, Zachary L.
• Tzeng, Stephany Y.
• Norman, James J.
• Anselmo, Aaron C.
• Xu, Xian
• Tomasic, Stephanie
• Taylor, Matthew A.
• Lu, Jennifer
• Guarecuco, Rohiverth
• Langer, Robert
• Jaklenec, Ana

Titel

Fabrication of fillable microparticles and other complex 3D microstructures

Ist Teil von

• Science (American Association for the Advancement of Science), 2017-09, Vol.357 (6356), p.1138-1142

Ort / Verlag

United States: American Association for the Advancement of Science

Erscheinungsjahr

2017

Link zum Volltext

Quelle

Science Online_科学在线

Beschreibungen/Notizen

• Three-dimensional (3D) microstructures created by microfabrication and additive manufacturing have demonstrated value across a number of fields, ranging from biomedicine to microelectronics. However, the techniques used to create these devices each have their own characteristic set of advantages and limitations with regards to resolution, material compatibility, and geometrical constraints that determine the types of microstructures that can be formed. We describe a microfabrication method, termed StampEd Assembly of polymer Layers (SEAL), and create injectable pulsatile drug-delivery microparticles, pH sensors, and 3D microfluidic devices that we could not produce using traditional 3D printing. SEAL allows us to generate microstructures with complex geometry at high resolution, produce fully enclosed internal cavities containing a solid or liquid, and use potentially any thermoplastic material without processing additives.