Details

Autor(en) / Beteiligte

• Chang, Cindy M
• Rostron, Brian L
• Chang, Joanne T
• Corey, Catherine G
• Kimmel, Heather L
• Sosnoff, Connie S
• Goniewicz, Maciej L
• Edwards, Kathryn C
• Hatsukami, Dorothy K
• Wang, Yuesong
• Del Valle-Pinero, Arseima Y
• Yang, Maocheng
• Travers, Mark J
• Arnstein, Stephen
• Taylor, Kristie
• Conway, Kevin
• Ambrose, Bridget K
• Borek, Nicolette
• Hyland, Andrew
• Wang, Lanqing
• Blount, Benjamin C
• van Bemmel, Dana M

Titel

Biomarkers of Exposure among U.S. Adult Cigar Smokers: Population Assessment of Tobacco and Health (PATH) Study Wave 1 (2013-2014)

Ist Teil von

• Cancer epidemiology, biomarkers & prevention, 2019-05, Vol.28 (5), p.943-953

Ort / Verlag

United States

Erscheinungsjahr

2019

Quelle

MEDLINE

Beschreibungen/Notizen

• Given the diverse cigar market and limited data on biomarker patterns by cigar type, we compared biomarkers of nicotine and tobacco toxicants among cigar smokers and other groups. Using Wave 1 urinary biomarker data from 5,604 adults in the Population Assessment of Tobacco and Health (PATH) Study, we compared geometric mean concentrations among cigar-only smokers (all cigars and separately for traditional, cigarillo, and filtered cigars), cigarette-only smokers, dual cigar/cigarette smokers, and never users of tobacco. We calculated geometric mean ratios comparing groups with never users adjusting for sex, age, race/ethnicity, education and creatinine. Some day cigar-only smokers had lower biomarker concentrations than every day cigar-only smokers, but higher than never users. Every day cigar-only smokers ( = 61) had lower TNE-2 (cotinine+trans-3'-hydroxycotinine) compared to every day cigarette-only ( = 2217; < 0.0001) and dual cigar/cigarette smokers ( = 601; < 0.0001). Several biomarkers, including NNAL (NNK metabolite) and CYMA (metabolite of acrylonitrile), were comparable in these groups. In exploratory analyses, every day filtered cigar-only ( = 7) smokers had higher biomarker concentrations compared with every day traditional cigar-only smokers ( = 12) and cigarillo-only smokers ( = 24). Every day smokers of each cigar type were similar to exclusive cigarette smokers. For some biomarkers, particularly for every day filtered cigar-only smokers, concentrations were higher. For some biomarkers, every day cigar-only smokers were comparable with every day cigarette-only smokers. Exploratory analyses suggest that biomarkers vary by cigar type with every day filtered cigar-only smokers having the highest concentrations. High exposure to harmful constituents among cigar smokers is a continuing health issue.