CNS neuroscience & therapeutics, 2018-12, Vol.24 (12), p.1275-1285
2018
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- Autor(en) / Beteiligte
- Titel
- Brain‐selective mild hypothermia promotes long‐term white matter integrity after ischemic stroke in mice
- Ist Teil von
- CNS neuroscience & therapeutics, 2018-12, Vol.24 (12), p.1275-1285
- Ort / Verlag
- England: John Wiley & Sons, Inc
- Erscheinungsjahr
- 2018
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Summary Introduction The neuroprotective effects of hypothermia in acute ischemic stroke are well documented. However, the mechanisms involved in the effects remain to be clearly elucidated and the role of hypothermia on long‐term white matter integrity after acute ischemic stroke has yet to be investigated. Aims To investigate the role of mild focal hypothermia on long‐term white matter (WM) integrity after transient cerebral ischemia. Results Mild focal hypothermia treatment immediately after ischemic stroke significantly promotes WM integrity 28 days after the occlusion of the middle cerebral artery (MCAO) in mice. Higher integrity of white matter, lower activation of total microglia, less infarct volume, and better neurobehavioral function were detected in hypothermia‐treated mice compared to normothermia‐treated mice. Furthermore, we found that hypothermia could decrease detrimental M1 phenotype microglia and promote healthy M2 phenotype microglia. In vitro, results also indicated that hypothermia promoted oligodendrocytes differentiation and maturation after oxygen glucose deprivation. Conclusion Hypothermia promotes long‐term WM integrity and inhibits neuroinflammation in a mouse model of ischemic brain injury.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1755-5930eISSN: 1755-5949DOI: 10.1111/cns.13061Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6489965
- Format
- –
- Schlagworte
- Animals, Animals, Newborn, Antigens - genetics, Antigens - metabolism, Antigens, CD - metabolism, Brain - physiology, Brain Infarction - etiology, Brain injury, Calcium-Binding Proteins - metabolism, Cell Hypoxia - physiology, Cells, Cultured, Cerebral blood flow, Cerebrum - cytology, Disease Models, Animal, Gene Expression Regulation - physiology, Glucose - deficiency, Hypothermia, Hypothermia, Induced - methods, Infarction, Middle Cerebral Artery - complications, Inflammation, Ischemia, Leukoencephalopathies - etiology, Leukoencephalopathies - therapy, Male, Maze Learning, Mice, Mice, Inbred C57BL, Microfilament Proteins - metabolism, Microglia, Myelin Basic Protein - genetics, Myelin Basic Protein - metabolism, Neurofilament Proteins - genetics, Neurofilament Proteins - metabolism, Neuroprotection, Oligodendrocytes, Oligodendroglia - metabolism, Original, Phenotypes, Proteoglycans - genetics, Proteoglycans - metabolism, Rats, Rats, Sprague-Dawley, RNA, Messenger - metabolism, Rodents, Rotarod Performance Test, Stroke, Substantia alba, Time Factors, white matter