Details

Autor(en) / Beteiligte

• Cai, Ling
• Lin, ShinYi
• Girard, Luc
• Zhou, Yunyun
• Yang, Lin
• Ci, Bo
• Zhou, Qinbo
• Luo, Danni
• Yao, Bo
• Tang, Hao
• Allen, Jeffrey
• Huffman, Kenneth
• Gazdar, Adi
• Heymach, John
• Wistuba, Ignacio
• Xiao, Guanghua
• Minna, John
• Xie, Yang

Titel

LCE: an open web portal to explore gene expression and clinical associations in lung cancer

Ist Teil von

• Oncogene, 2019-04, Vol.38 (14), p.2551-2564

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2019

Link zum Volltext

Quelle

Nexis

Beschreibungen/Notizen

• We constructed a lung cancer-specific database housing expression data and clinical data from over 6700 patients in 56 studies. Expression data from 23 genome-wide platforms were carefully processed and quality controlled, whereas clinical data were standardized and rigorously curated. Empowered by this lung cancer database, we created an open access web resource-the Lung Cancer Explorer (LCE), which enables researchers and clinicians to explore these data and perform analyses. Users can perform meta-analyses on LCE to gain a quick overview of the results on tumor vs non-malignant tissue (normal) differential gene expression and expression-survival association. Individual dataset-based survival analysis, comparative analysis, and correlation analysis are also provided with flexible options to allow for customized analyses from the user.