Details

Autor(en) / Beteiligte

• Williams, Jade C
• Sheldon, Jessica R
• Imlay, Hunter D
• Dutter, Brendan F
• Draelos, Matthew M
• Skaar, Eric P
• Sulikowski, Gary A

Titel

Synthesis of the Siderophore Coelichelin and Its Utility as a Probe in the Study of Bacterial Metal Sensing and Response

Ist Teil von

• Organic letters, 2019-02, Vol.21 (3), p.679-682

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2019

Quelle

MEDLINE

Beschreibungen/Notizen

• A convergent total synthesis of the siderophore coelichelin is described. The synthetic route also provided access to acetyl coelichelin and other congeners of the parent siderophore. The synthetic products were evaluated for their ability to bind ferric iron and promote growth of a siderophore-deficient strain of the Gram-negative bacterium Pseudomonas aeruginosa under iron restriction conditions. The results of these studies indicate coelichelin and several derivatives serve as ferric iron delivery vehicles for P. aeruginosa.